Jengkol leaves (Archidendron jiringa Benth) contain active compounds such as flavonoids, saponins, steroids and tannins. the use of herbal medicines during pregnancy must be considered carefully, because drugs can cross the placenta and so can cause teratogenic effects on the fetus. Teratogenic toxicity research of ethanol extract of jengkol leaves (Archidendron jiringa Benth) has been conducte…
The ethanol extract of Pelawan leaves (Tristaniopsis merguensis Griff.) contains flavonoids, steroids, phenolics, and terpenoids, which have the potential to act as analgesics and anti-inflammatory agents due to their ability to inhibit prostaglandin formation, the main mediator of pain and inflammation. This study aimed to evaluate the characteristics of the extract as well as the analgesic an…
The use of antioxidants can prevent oxidative stress conditions, which cause tissue damage, due to too many free radicals in the body. The body produces antioxidant compounds such as SOD (Superoxide Dismutase), Gpx (Glutathione peroxidase), and catalase to protect the endothelium of blood vessels from free radical attacks, which reduce oxidative stress. This study aims to evaluate the antioxida…
The human body that is exposed to excess free radicals in a prolonged period can cause oxidative stress and various diseases so antioxidant compounds are needed to counteract free radicals. This study was conducted with the aim of determining the strongest antioxidant activity of ciplukan leaves, guava leaves, katuk leaves and cat whisker leaves that have been used empirically by the people of …
The red onion (Allium cepa L.) have a skin that contained active compounds such as flavonoids, steroids, and phenolics that have the potential as antioxidants, one of which can be used as a hair growth stimulant. This study aimed to optimize the use of gelling agents in hair serum formulations of red onion peel extract (Allium cepa L.) as a hair growth stimulant. The formula optimization was de…
Benign Prostatic Hyperplasia (BPH) is a benign prostate enlargement that is common in elderly men. Drug therapy is the main choice treatment of BPH, but patients are susceptible to non-compliance due to long-term treatment or side effects of drugs. Non-compliance with drug use can affect the patient's quality of life. The purpose of this study was to analyze the relationship between drug compli…
Pomegranate (Punica granatum L.) peel has been proven to contain secondary metabolites, one of which is the phenolic group in the form of ellagic acid which has potential ability as a treatment for hyperpigmentation. The deformability and elasticity of transethosomes can penetrate the stratum corneum and increase the transfer of active substances in skin permeability. This study aims to determi…
Red onion skin (Allium cepa L.) has been proven to promote hair growth due to its strong antioxidant activity. Transfersomes were capable of penetrating the transfollicular pathways to enhance the antioxidant effect of quercetin compounds in red onion skin extract. This study aims to optimize the transfersome formula of red onion skin extract by varying the concentrations of phospholipon 90G an…
Gamal leaves (Gliricidia sepium) have pharmacological activity as anthelmitic, hepatoprotector and antibacterial. The content of secondary metabolites in the ethyl acetate fraction of gamal leaves are flavonoids, tannins and saponins. The purpose of this study was to determine the effects of acute toxicity of the ethyl acetate fraction of gamal leaves with testing parameters of biochemical leve…
Kidney stones (nephrolithiasis) were a common health problem in Indonesia. The kersen leaf (Muntingia calabura L.) contained flavonoid compounds that acted as diuretics. The use of nanosuspension preparations was chosen to enhance the effectiveness and bioavailability of the fraction in delivering the active substance to the target. The aim of this study was to determine the %EE and characteriz…
Daun kersen (Muntingia calabura L.) diketahui memiliki efek farmakologi sebagai antinefrolitiasis karena mengandung senyawa flavonoid yang dapat berikatan dengan kalsium pada batu ginjal dan meningkatkan ekskresi urin. Senyawa bahan alam mempunyai kelarutan dan bioavailabilitas yang rendah dalam air sehingga dapat diatasi dengan inovasi sediaan berupa nanosuspensi. Penelitian ini bertujuan untu…
Asam kandis (Garcinia parvifolia (Miq.) Miq) merupakan tanaman tropis yang termasuk dalam famili Clusiaceae, yang banyak digunakan dalam pengobatan tradisional di Indonesia dan daerah tropis lainnya. Penelitian ini bertujuan untuk mengevaluasi efek analgetika dan antiinflamasi dari ekstrak dan fraksi daun asam kandis (Garcinia parvifolia (Miq.) Miq) pada tikus putih jantan. Penelitian ini mengg…
Daun sukun (Artocarpus altilis) merupakan salah satu tanaman obat potensial dengan berbagai khasiat. Namun, penggunaan daun sukun sebagai obat tradisional belum diketahui tingkat keamanannya. Penelitian ini bertujuan untuk mengetahui efek toksisitas subkronis ekstrak etanol daun sukun (Artocarpus altilis) pada tikus putih galur wistar. Pengujian dilakukan selama 28 hari dengan pemberian sediaan…
The main component of polyphenolic compounds in gambier sap extract is catechin, a flavonoid compound with anti-inflammatory properties that can help relieve inflammatory. Catechins have low solubility and bioavailability, resulting in its to deliver into the body. In this research, gambier sap extract was formulated using a drug delivery technology system in the form of Self-Nano Emulsion syst…
Lawsonia inermis is a traditional medicinal plant used to treat inflammation of the finger joints and skin diseases.The aims of This study were evaluated the efficacy of Lawsonia inermis leaf extract in healing burn and incision wounds. The extraction was carried out using the maceration method with ethanol solvent.The research were used 60 male Wistar rats, divided into six treatment groups (f…
Pain and inflammation are common health issues experienced by patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat these conditions, but they come with undesirable side effects. Traditional medicine using Gelam leaves (Melaleuca leucadendra L.) may offer a promising alternative with potential analgesic and anti-inflammatory properties. Secondary metabolites in Gelam …
Jatropha curcas linn leaves contain secondary metabolite compounds such as alkaloids, flavonoids (kaemperol), saponins, steroids, tannins, quinones, and phenols. Empirically, this study aims to determine the characteristics and phytochemical screening of ethanol extracts and fractions of Jatropha curcas leaves, the effect of administering ethanol extracts and fractions on MDA levels, catalase e…
Purple Paper Flower (Bougainvillea spectabilis) has traditionally been used to treat various diseases such as hepatitis, ulcers, vaginal discharge, and irregular menstruation. Its secondary metabolite compounds include alkaloids, flavonoids, phenols, quinones, saponins, steroids, tannins, and terpenoids, which have potential to accelerate wound healing. This study aims to identify the character…
The Takokak plant (Solanum torvum Sw.) contains phenolic compounds, flavonoids, glycosides, tannins, sterols, saponins, alkaloids, triterpenes, anthraquinones, and anthocyanins, which have potential as natural antioxidants. This study aimed to determine the total phenolic and flavonoid content, antioxidant activity (IC50), and inhibition percentage of ethanol extracts from the roots, flowers, f…
Breadfruit leaves (Artocarpus altilitis) are one of the herbal medicines that have activity as antihyperglycemia, antibacterial, anti-inflammatory, and antihypertensive. From the results of phytochemical screening, it is known that ethanol extract of breadfruit leaves contains phenolics, saponins, tannins, flavanoids, polyphenols, hydrocyanic acid, acetylcholine, riboflavin. The safety of using…
Bandotan leaves are known to contain alkaloids, flavonoids, tannins, saponins, triterpenoids, steroids, and phenolics. This research aims to analyze the characteristics, phytochemical composition, impact of administration of ethanol extracts and bandotan leaf fractions on antioxidant activity. The assessed parameters include MDA levels, catalase enzyme activity, macroscopic liver observations a…
Penelitian aktivitas antidiabetes ekstrak dan fraksi buah karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) terhadap tikus putih jantan galur wistar terinduksi streptozotosin bertujuan mengetahuipengaruhpemberianekstraketanoldan fraksi etil asetat buah karamuntingterhadappenurunankadarglukosadarahtikusdiabetes mellitus tipe-2 dan mengetahuidosisefektifdarivariasiekstraketanol dan fraksi etil as…
Hyperlipidemia is characterized by increased normal levels of plasma lipids such as cholesterol, triglycerides, cholesterol esters, phospholipids, and sometimes plasma lipoproteins, including very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), along with decreased high-density lipoproteins (HDL). This study used an in silico approach to predict the molecular potential of be…
Long-term exposure to excess free radicals in the body can cause oxidative stress and various diseases, so antioxidant compounds are needed to neutralize free radicals. This research was conducted to determine the strongest antioxidant activity of avocado leaves, water guava leaves and cherry leaves which have been used empirically by the Ogan Ilir community. The extract with the strongest anti…
Ibuprofen Is Classified As A Bcs Class Ii Biopharmaceutical. This Means That Researchers Use Solid Dispersion To Improve Its Solubility And Dissolution Rate, As It Has Poor Oral Solubility And Bioavailability. This Study Used A Combination Of Chitosan And Sodium Alginate To Form Solid Dispersion With Co-Grinding Technique, Which Is Easy To Do And Environmentally Friendly. In The Preparation Of …
Hyperlipidemia is a disorder of the fat metabolism system which causes an increase in total cholesterol, LDL, triglyceride levels and a decrease in blood HDL. Catechin is the main compound from gambier leaves, including flavonoid compounds which can reduce hyperlipidemia. The aim of this research was to determine the effect of administering self-nano emulsion from gambier leaf extract on lipid …