Infections caused by antibiotic-resistant bacteria, particularly carbapenem-resistant Pseudomonas aeruginosa (CRPA), have become a significant global health issue. Pseudomonas aeruginosa is a common nosocomial pathogen that often demonstrates resistance to many antibiotics. Given the rising cases of antibiotic resistance, alternative treatments are needed, one of which involves utilizing the po…
One of the obstacles in tilapia cultivation is the Aeromonas hydrophila bacteria that causes Motile Aeromonas Septicemia (MAS) disease. This disease can be overcome by using natural ingredients. One of the natural ingredients that can be used to treat bacterial diseases in fish is the stem of brotowali (Tinospora crispa L.). The use of the stem of brotowali has been proven in vitro to inhibit A…
Sebuah ulasan tentang tanaman obat yang dipakai secara turun temurun untuk mengatasi tiga penyakit utama masyarakat dewasa yaitu diabetes, asam urat, dan tekanan darah tinggi. Penyakit-penyakit tersebut sangat banyak diderita masyarakat Indonesia dari kelas bawah sampai kelas atas. Beberapa keuntungan pemakaian obat tradisional dalam mengatasi masalah kesehatan adalah biaya yang lebih murah, ef…
Staphylococcus aureus infection is caused by a bacterium that colonizes various organs in the human body, particularly the upper respiratory tract, including the skin, nasal cavity, axilla, and inguinal area. The emergence of antibiotic-resistant S. aureus, known as MRSA and VRSA, presents a significant challenge in the treatment of such infections. Natural products, such as the torch ginger fl…
This study aims to determine the effect of the use of ethanol extract of temu mango rhizome (Curcuma mangga Val) on anti-inflammatory in mice (Mus musculus) Swiss Webster Strain. The method used is an experimental method with a completely randomized design (RAL) design consisting of 5 treatments and 6 replicates. The treatment consisted of one negative control group (Aquades), one positive cont…
This study aims to determine the effect of aqueous extract of Curcuma mangga Val. rhizome on the anti-inflammatory response in mice (Mus musculus). The study employs an experimental method with a completely randomized design (CRD) consisting of five treatment groups: a negative control (aqueous solution), a positive control (Sodium Diclofenac 0.13 mg/kgBW), and three doses of Curcuma mangga rhi…
flavonoid compounds and has the potential as an antihyperuricemia. This study aims to evaluate the antihyperuricemia activity of ethanol extract of B. spectabilis in male white rats of the Wistar strain. Extraction was carried out by the maceration method using 96% ethanol. The extract was characterized and tested the antihyperuricemia activity used 35 rats male were divided into 7 groups: norm…
Lawsonia inermis L. is one of the traditional medicinal plants that are effective as analgesics. The analgesic effect was related to the ability of the substance to reduced uric acid levels (antihyperuricemia). This study aims to determine the antihyperuricemia activity of ethanol extract of L. inermis leaves using male white rats of the Wistar strain induced in hyperuricemia condition. The stu…
The ethanol extract of seburo leaves (Garcinia forbesii King) contains flavonoid, alkaloid, phenolic, saponin and steroid compounds which are potentially active as an analgesic and anti-inflammatory. This study aims to determine the characteristics of the extract as well as the analgesic and anti-inflammatory effects of the ethanol extract and fractions with different solvent polarities from se…
The sungkai leaf (Peronema canescens jack.) is known to contain flavonoid compounds with potential diuretic properties. This study aimed to evaluate the diuretic activity of ethanolic extract from sungkai leaves through preclinical tests on experimental animals divided into six treatment groups. These groups consisted of a normal control (aquadest), a negative control (NaCMC), a positive contro…
The Kardia plant (Bellucia Pentamera Naudin), a member of the Melastomataceae family, contains compounds such as steroids, triterpenoids, and flavonoids, which exhibit potential analgesic and anti-inflammatory properties. This study aims to characterize the extract and evaluate its analgesic and anti-inflammatory effects based on the reduction in writhing behavior in mice and edema volume in ra…
Free radical that can cause damage to body cells by oxidative stress as a trigger factor for degenerative diseases with the presence of antioxidant compounds able to counteract free radical. Medical plants ciplukan, guajava, katuk, and cat’s whiskers are utilized as antihypertensive traditional medicine because their bioactive compounds support blood pressure control. This study was conducted…
Moringa leaf (Moringa oleifera L.) are proven to contain secondary metabolites, one of which is flavonoids in the form of quercetin which has the ability as an anticancer. This study aims to determine the optimum formula of nanoparticles from a variety of alginate chitosan coatings at concentrations of 0.3% and 0.6% conjugated with folic acid. Moringa leaf extract was obtained through maceratio…
Andrographis paniculata (Burm.f.) Nees) contains andrografolid, a compound that has anti-inflammatory, antibacterial, and antioxidant activities to accelerate burn wound healing. This study evaluated the preparation of submicro emulsion of bitter melon leaf extract with Tween 20 and PEG-400 at a concentration of 10% and tested the burn wound healing activity in Wistar rats. This study was divid…
Kenikir leaves (Cosmos caudatus Kunth.) contain flavonoid group compound quercetin which has potential as anti-cancer. The extract of kenikir leaves has low solubility and bioavailability so that a modification of the drug delivery system is needed in the form of folic acid-conjugated chitosan-alginate polymer-based nanoparticles. Folic acid-conjugated chitosan carries the drug to folate recept…
Gnetum gnemon leaves contained flavonoids that had the potential to dissolve kidney stones by increasing urinary citrate excretion and diuresis. The low bioavailability of fractions required nanoparticle dosage forms as an option to increase the effectiveness of the delivery system. This study aimed to determine the percentage of nanosuspension entrapment efficiency used for in vivo tests and t…
Inflammation is the body's protective mechanism against tissue damage caused by physical trauma, chemical irritation, or microbial infection. However, the use of synthetic anti-inflammatory drugs, such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), often leads to side effects, including gastrointestinal irritation and impaired kidney function. Sambiloto (Andrographis paniculata) is an herba…
Gamal leaves (Gliricidia sepium) have pharmacological activity as anthelmitic, hepatoprotector and antibacterial. The content of secondary metabolites in the ethyl acetate fraction of gamal leaves are flavonoids, tannins and saponins. The purpose of this study was to determine the effects of acute toxicity of the ethyl acetate fraction of gamal leaves with testing parameters of biochemical leve…
Kidney stones (nephrolithiasis) were a common health problem in Indonesia. The kersen leaf (Muntingia calabura L.) contained flavonoid compounds that acted as diuretics. The use of nanosuspension preparations was chosen to enhance the effectiveness and bioavailability of the fraction in delivering the active substance to the target. The aim of this study was to determine the %EE and characteriz…
Daun kersen (Muntingia calabura L.) diketahui memiliki efek farmakologi sebagai antinefrolitiasis karena mengandung senyawa flavonoid yang dapat berikatan dengan kalsium pada batu ginjal dan meningkatkan ekskresi urin. Senyawa bahan alam mempunyai kelarutan dan bioavailabilitas yang rendah dalam air sehingga dapat diatasi dengan inovasi sediaan berupa nanosuspensi. Penelitian ini bertujuan untu…
Long-term exposure to excess free radicals in the body can cause oxidative stress and various diseases, so antioxidant compounds are needed to neutralize free radicals. This research was conducted to determine the strongest antioxidant activity of avocado leaves, water guava leaves and cherry leaves which have been used empirically by the Ogan Ilir community. The extract with the strongest anti…
The utilization of sweet orange peel is still minimal as it is often overlooked after fruit processing for consumption, despite being rich in bioactive compounds, including flavonoids, especially for topical preparations. Previous research has mainly focused on conventional formulations with limitations in skin penetration. The Nanostructured Lipid Carrier (NLC) delivery system can enhance perc…
Excessive free radicals in the body can cause oxidative stress conditions which result in tissue damage. This condition can be prevented by consuming antioxidants. Cherry leaves (Muntigia calabura L.) often used as a medicinal plant and are believed to have antioxidant properties. Based on previous research, methanol extract of cherry leaves has strong antioxidant activity, while the ethyl acet…
Kersen leaves (Muntingia calabura L.) have been proven to have antioxidant properties, both in the form of crude extracts and fractions. The ethyl acetate fraction of kersen leaves separated by vacuum liquid column chromatography has strong antioxidant activity (IC50 43,40 µg/mL). This research is a continuation of the previous research by further separating the fraction of vacuum liquid colum…
Plants that contain high levels of flavonoid and phenol compounds have the potential to act as antioxidants and anti-inflammatories. One of them is the breadfruit plant (Artocarpus altilis). This study aims to determine the antioxidant and anti-inflammatory activity of breadfruit leaf fractions. The research began with extraction by maceration using solvents with varying polarities (n-hexane, e…
Separation of metabolite compounds from the n-hexane fraction of the wood of the M. alba L. plant has not been widely carried out. TLC analysis showed that M. alba L. has many metabolite compounds. This research was aimed to determine metabolite compounds from the n-hexane fraction of the wood of the M. alba L. plant using the gas chromatography-mass spectrometry (GC-MS) method. The extraction …
Morus alba L. is a plant from Moraceae family which is found in tropical and subtropical areas. M. alba plant was reported to have displayed several bioactivities such as antioxidant, antitumor, antibacterial, anticancer, antidiabetic, and anti-inflammatory. M. alba plant has a diversity of secondary metabolites. This research was aimed to isolate and identify secondary metabolite compounds fro…