Pendahuluan: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis kronik memiliki risiko tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat kondisi imunokompromais. Defisiensi vitamin D diketahui berperan dalam penurunan respons imun terhadap Mycobacterium tuberculosis. Namun, hubungan antara kadar vitamin D 25(OH) dengan kejadian ILTB pada populasi hemodialisis di Indonesia m…
Latar Belakang: Pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis memiliki risiko lebih tinggi mengalami infeksi laten tuberkulosis (ILTB) akibat disfungsi imun dan kondisi inflamasi kronis. High-sensitivity C-reactive protein (hsCRP) merupakan penanda inflamasi yang sering meningkat pada populasi ini, namun hubungannya dengan kejadian ILTB masih belum jelas terutama di Indonesia.…
Latar Belakang : Penuaan menyebabkan penurunan massa otot, kekuatan otot, dan performa fisik akibat proses inflamasi kronik derajat rendah yang ditandai peningkatan enzim COX-2 dan ROS. EVOO mengandung senyawa fenolik seperti oleocanthal dan hydroxytyrosol yang bersifat antioksidan dan antiinflamasi melalui inhibisi jalur NF-κB–COX-2, sehingga berpotensi menekan inflamasi dan mempertahankan …
Latar Belakang: Osteoartritis (OA) lutut merupakan salah satu penyakit sendi degeneratif yang ditandai dengan penipisan kartilago hialin dan inflamasi kronik. Vitamin D memiliki peran penting dalam metabolisme tulang, modulasi respon imun, dan aktivitas kondrosit. Penurunan kadar vitamin D serum diduga berhubungan dengan penurunan ketebalan kartilago hialin. OA menjadi masalah global karena dap…
This research aims to analyze the implementation of government economic policies regarding the South Sumatra Indonesian Young Entrepreneurs Association (HIPMI) in an effort to develop Micro, Small, and Medium Enterprises (MSMEs) in Palembang City. Utilizing the implementation model by Van Meter and Van Horn, this study evaluates six key dimensions: policy standards and objectives, resources, ch…
Background: Gastric adenocarcinoma remains a global health burden with high mortality, while effective targeted therapies are still limited. Claudin-18.2 is a transmembrane tight-junction protein selectively expressed in normal gastric mucosa and retained in gastric adenocarcinoma. Its role as a novel therapeutic target, including zolbetuximab, highlights the importance of investigating claudin…
ASSOCIATION BETWEEN RADIOLOGICAL EXAMINATION AND PIRANI SCORE IN PATIENTS WITH CONGENITAL TALIPES EQUINOVARUS (CTEV) WITH PONSETTI METHOD MANAGEMENT AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANG Abstraìct Baìckground: Clinicaìl feaìtures of deformity haìve been claìssified by Piraìni, so thaìt its severity caìn be aìssessed aìt birth aìnd the progress of treaìtment caìn be mon…
Background: Vulvovaginal candidiasis (VVC) is a very common mucosal infection in the vagina and vulva, mostly caused by Candida albicans. Accurate diagnosis requires supportive examinations such as direct microscopic evaluation or fungal culture; however, in practice, these ancillary tests are often omitted in women presenting with vulvovaginal symptoms due to high patient burden and the need f…
Procedural pain is a common clinical issue in neonates, particularly during venipuncture. Inadequately managed pain can trigger physiological stress, hemodynamic instability, and may negatively affect long-term neurodevelopment. Non-pharmacological analgesic strategies such as oral dextrose have become a practical option due to their simplicity, safety, and ability to reduce reliance on pharmac…
Anak dengan hemofilia memiliki risiko tinggi mengalami artropati sendi akibat perdarahan berulang. Penelitian ini bertujuan untuk mengidentifikasi faktor risiko yang berhubungan dengan artropati tahap lanjut pada pasien anak dengan hemofilia. Penelitian observasional analitik dengan desain potong lintang dilakukan di RS Mohammad Hoesin Palembang pada Januari hingga Juni 2025. Sebanyak 42 anak d…
Children with Virtual Autism (VA) are at risk of developing social, emotional, and communication disorders due to excessive exposure to digital media. This study aims to determine the prevalence and risk factors of VA in children. An observational analytic study with a cross-sectional design was conducted at RSUP Dr. Mohammad Hoesin Palembang from February 2025 to June 2025. The study involved …
Background: Vitamin D deficiency is an emergency problem in Indonesia with a prevalence rate of 33% in all children and young adults and can affect the function in the field of orthopedics and traumatology, especially in the physical performance of the musculoskeletal system even there was controversial in level of molecular theory. This study aims to determine correlation of serum vitamin D le…
SAC dan CPA merupakan prosedur ACDF yang sering dilakukan pada pasien dengan stenosis kanalis servikalis. Kedua metode prosedur pembedahan tersebut menunjukkan fusion rate yang sebanding. Penelitian ini bertujuan untuk menganalisis asosiasi antara prosedur ACDF-SAC dan ACDF-CPA dengan fusion rate pada single level degenerative subaxial cervical stensosis di Rumah Sakit Umum Dr Mohammad Hoesin P…
Background: Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in Indonesia, with the majority of patients presenting at an advanced stage. Vitamin D has been suggested to play a role in improving treatment response, but clinical evidence remains limited. This study aimed to evaluate the effectiveness of vitamin D supplementation on treatment response in NPC patients undergoi…
Latar Belakang: Karsinoma nasofaring merupakan keganasan epitel mukosa yang sering ditemukan di Asia Tenggara, termasuk Indonesia, dengan tingkat kesintasan rendah akibat sifatnya yang agresif dan penyebaran limfatik maupun hematogen yang cepat. Penanda proliferasi Ki67 berperan penting dalam menilai aktivitas pembelahan sel tumor, memprediksi prognosis, serta mengevaluasi respons terhadap kemo…
Background: High-resolution computed tomography (HRCT) imaging of the temporal bone prior to mastoidectomy is a routine examination in the field of Otorhinolaryngology–Head and Neck Surgery (ENT-HNS). HRCT findings play an important role in the medical and surgical management of patients with chronic suppurative otitis media (CSOM). In addition, HRCT can serve as the basis for planning the su…
Background: Acute diffuse otitis externa is an inflammation of the skin and subcutaneous tissue of the external auditory canal, commonly caused by bacterial infection, particularly Pseudomonas aeruginosa and Staphylococcus aureus. Treatment involves ear canal cleaning, pain control, and topical antibiotic therapy using ear tampons. Single antibiotic tampons effectively treat infection but lack …
Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in chronic haemodialysis patients. Conventional assessment of systolic function using left ventricular ejection fraction (LVEF) is often less sensitive in detecting subclinical myocardial dysfunction that impacts short-term prognosis. Left ventricular Global Longitudinal Strain (GLS) is suspected to be closely …
Background: Sarcopenia is a progressive skeletal muscle disorder characterized by a decline in muscle strength, mass, and physical performance, leading to increased fall risks and reduced quality of life in the elderly. The pathogenesis is driven by "inflammaging," particularly elevated levels of Interleukin 6 (IL-6). Given the rising geriatric population in Palembang, early detection through c…
Background: As people age, the human body undergoes physiological changes, including a progressive reduce of skeletal muscle mass and strength, known as sarcopenia. The diagnosis of sarcopenia is based on calf circumference screening, also measurement of muscle mass, muscle strength, and physical performance. The primary factors contributing to sarcopenia are systemic inflammation and oxidative…
Background Elderly individuals represent a population with a high potential for a decline in the quantity and quality of skeletal muscles, a condition known as sarcopenia. Muscle quantity refers to the reduction in muscle mass, while muscle quality can be assessed through muscle strength and physical performance as age advances. Sarcopenia significantly reduces the ability to perform daily func…
Background: The presence of a malignant pleural effusion (MPE) indicates advanced stage in malignancy, which severely compromises in a poor prognosis. The LENT score has been developed as a prognostic tool for MPE, yet its association with pleural effusion progression and six-month survival has not been thoroughly evaluated, particularly in Indonesia. Methods: This prospective cohort study incl…
Background: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from impaired insulin secretion or insulin resistance, with chronic low-grade inflammation playing a role in its pathogenesis. Diacerein has anti-inflammatory effects and improves insulin sensitivity; however, clinical evidence in Indonesia remains limited. Objective: To evaluate the effect of adding diacere…
Background: Acute Coronary Syndrome (ACS) is one of the leading causes of mortality and hospitalization due to cardiovascular disease. Variations in patient characteristics and the presence of metabolic risk factors may influence the occurrence and prognosis of ACS. Therefore, understanding the profile of ACS patient characteristics is essential as a basis for preventive planning and clinical s…
Background: STEMI is an acute condition caused by obstruction of blood flow to the heart, leading to cardiomyocyte necrosis. This process begins with the formation of atherosclerotic plaques that cause total occlusion of the coronary artery lumen, resulting in myocardial ischemia. When transmural ischemia lasts for 20–40 minutes, cardiomyocyte necrosis occurs. Methods: This study aimed to des…
Background: Type 2 Diabetes Mellitus (T2DM) was a chronic metabolic disease with an increasing prevalence, accompanied by hepatic complications such as Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD). The duration of T2DM affected the severity of metabolic disturbances, insulin resistance, and hepatic fat accumulation. However, data on the incidence of MAFLD at RSUP Dr. Mohammad …
Background. Low back pain (LBP) is one of the most common musculoskeletal complaints and can adversely affect physical function, quality of life, and patient productivity. Vitamin D deficiency, assessed through serum 25-hydroxyvitamin D (25-OH D) levels, plays a role in pain modulation, muscle function, and inflammatory responses, and is suspected to be associated with LBP occurrence. This stud…
Urothelial carcinoma is the most common malignancy of the urinary tract and exhibits a wide range of clinicopathological characteristics that influence prognosis and patient management. Local data regarding the clinicopathological characteristics of urothelial carcinoma in Palembang remain limited; therefore, this study was conducted to provide a more representative overview. This study was a d…
Background: Chronic Kidney Disease (CKD) is a progressive condition that requires long-term hemodialysis treatment. Hemodialysis results are greatly influenced by vascular access, especially Arteriovenous Shunt (AV Shunt) as permanent access and Double Lumen Catheter (CDL) as temporary access. The difference between the patient's characteristics and the clinical condition is often a factor in t…
Background: Bone marrow trephine biopsy is an essential diagnostic procedure for hematological diseases through assessment of morphology, fibrosis, cellularity, and tumor involvement. Since 2023, Dr. Mohammad Hoesin General Hospital Palembang has routinely performed bone marrow biopsies; however, clinicohistopathological data remain limited. This study aimed to describe the bone marrow clinicoh…