Leucas lavandulaefolia is traditional medicinal plant used to treat inflammation the finger joints and skin diseases. The aims of This study to were evaluated efficacy of Leucas lavanduleafolia leaf extract in healing burn and incision wounds. The extraction was carried out using maceration method ethanol solvent. The research used were 60 male Wistar rats, divided into six treatment groups (fi…
Kecombrang (Etlingera elatior) belongs to the zingiberaceae family and the rhizome of the combrang is widely used by the community as an antioxidant. Orally dissolving film preparations can neutralize the sour taste of kecombrang flowers. The results of the total flavonoid content contained 7.700%. The FII formula was determined to be the best formula for evaluating the uniformity of levels and…
Excessive free radical production can lead to oxidative stress that damages DNA, proteins and lipids, triggering serious neurodegenerative and autoimmune diseases. Oxidative damage caused by free radicals can be prevented by the activity of antioxidant compounds. Based on previous research, papaya leaves, melinjo leaves, and pelawan leaves as natural antioxidants contain flavonoids and phenolic…
Jengkol leaves (Archidendron jiringa Benth) contain active compounds such as flavonoids, saponins, steroids and tannins. the use of herbal medicines during pregnancy must be considered carefully, because drugs can cross the placenta and so can cause teratogenic effects on the fetus. Teratogenic toxicity research of ethanol extract of jengkol leaves (Archidendron jiringa Benth) has been conducte…
The ethanol extract of Pelawan leaves (Tristaniopsis merguensis Griff.) contains flavonoids, steroids, phenolics, and terpenoids, which have the potential to act as analgesics and anti-inflammatory agents due to their ability to inhibit prostaglandin formation, the main mediator of pain and inflammation. This study aimed to evaluate the characteristics of the extract as well as the analgesic an…
The use of antioxidants can prevent oxidative stress conditions, which cause tissue damage, due to too many free radicals in the body. The body produces antioxidant compounds such as SOD (Superoxide Dismutase), Gpx (Glutathione peroxidase), and catalase to protect the endothelium of blood vessels from free radical attacks, which reduce oxidative stress. This study aims to evaluate the antioxida…
The human body that is exposed to excess free radicals in a prolonged period can cause oxidative stress and various diseases so antioxidant compounds are needed to counteract free radicals. This study was conducted with the aim of determining the strongest antioxidant activity of ciplukan leaves, guava leaves, katuk leaves and cat whisker leaves that have been used empirically by the people of …
The red onion (Allium cepa L.) have a skin that contained active compounds such as flavonoids, steroids, and phenolics that have the potential as antioxidants, one of which can be used as a hair growth stimulant. This study aimed to optimize the use of gelling agents in hair serum formulations of red onion peel extract (Allium cepa L.) as a hair growth stimulant. The formula optimization was de…
Benign Prostatic Hyperplasia (BPH) is a benign prostate enlargement that is common in elderly men. Drug therapy is the main choice treatment of BPH, but patients are susceptible to non-compliance due to long-term treatment or side effects of drugs. Non-compliance with drug use can affect the patient's quality of life. The purpose of this study was to analyze the relationship between drug compli…
Pomegranate (Punica granatum L.) peel has been proven to contain secondary metabolites, one of which is the phenolic group in the form of ellagic acid which has potential ability as a treatment for hyperpigmentation. The deformability and elasticity of transethosomes can penetrate the stratum corneum and increase the transfer of active substances in skin permeability. This study aims to determi…
Red onion skin (Allium cepa L.) has been proven to promote hair growth due to its strong antioxidant activity. Transfersomes were capable of penetrating the transfollicular pathways to enhance the antioxidant effect of quercetin compounds in red onion skin extract. This study aims to optimize the transfersome formula of red onion skin extract by varying the concentrations of phospholipon 90G an…
Gamal leaves (Gliricidia sepium) have pharmacological activity as anthelmitic, hepatoprotector and antibacterial. The content of secondary metabolites in the ethyl acetate fraction of gamal leaves are flavonoids, tannins and saponins. The purpose of this study was to determine the effects of acute toxicity of the ethyl acetate fraction of gamal leaves with testing parameters of biochemical leve…
Kidney stones (nephrolithiasis) were a common health problem in Indonesia. The kersen leaf (Muntingia calabura L.) contained flavonoid compounds that acted as diuretics. The use of nanosuspension preparations was chosen to enhance the effectiveness and bioavailability of the fraction in delivering the active substance to the target. The aim of this study was to determine the %EE and characteriz…
Daun kersen (Muntingia calabura L.) diketahui memiliki efek farmakologi sebagai antinefrolitiasis karena mengandung senyawa flavonoid yang dapat berikatan dengan kalsium pada batu ginjal dan meningkatkan ekskresi urin. Senyawa bahan alam mempunyai kelarutan dan bioavailabilitas yang rendah dalam air sehingga dapat diatasi dengan inovasi sediaan berupa nanosuspensi. Penelitian ini bertujuan untu…
Pain and inflammation are common health issues experienced by patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used to treat these conditions, but they come with undesirable side effects. Traditional medicine using Gelam leaves (Melaleuca leucadendra L.) may offer a promising alternative with potential analgesic and anti-inflammatory properties. Secondary metabolites in Gelam …
This study aims to determine the antioxidant activity of purple sweet potato leaf ethanol fraction against decreased levels of malondialdehyde (MDA) blood plasma and mouse pancreas in vivo by TBARS method. The ethanol fraction of purple sweet potato leaves is obtained using a multilevel maceration method using n-hexane solvent, ethyl acetate and ethanol 96%. The test animals were grouped into 6…
The aims of this study are to determine the antioxidant activity of purple sweet potato leaves in inhibiting lipid peroxidation of blood and pancreas in rats. The solvent used is n-hexane, which is non polar solvent. The test of antioxidant activity using TBARS method by measuring the levels of malondialdehyde (MDA) plasma and pancreas induced by alloxan 150 mg/kg BW. The test animals were grou…
Uji Aktivitas Hepatoprotektor Ekstrak Etanol Kulit Buah Cempedak (Artocarpus champeden) Terhadap Kerusakan Hati Pada Tikus Putih Jantan Galur Wistar Terinduksi CCl4 Peggy Yulianda Jurusan Farmasi FMIPA Universitas Sriwijaya Abstract Cempedak peel is one of the plants that has the potential to be a source of antioxidants as an antidote to free radicals. The skin of cempedak peel ethanol extract …
Flacourtia rukam is a plant that has been used traditionally, one of its benefits as a treatment for diarrhea and dysentry. The aims of this study to isolated secondary metabolites from the methanol fraction of rukam leaves and their antibacterial activity test against Salmonella typhi and Shigella dysentriae. This research was started by maseration method using solvent with increasing polarity…
Salmonella typhi is gram negative bacteria caused typhoid fever. Typhoid fever highest cases in development country in south asian and southeast asian included Indonesian. A.conyzoides in empiric is using as herbal plant for typhoid fever treatment in Indonesian.This experiment was conducted to evaluate antibacterial activity of ethanol extract A.conyzoides leaves on rats has been infected. Cru…
Antioksidan merupakan substansi yang diperlukan tubuh untuk menetralisir radikal bebas dan mencegah kerusakan yang ditimbulkan oleh radikal terhadap melanosit pada kulit. Ekstrak daun kirinyuh (Chromolaena odorata) mengandung flavonoid yang berpotensi sebagai antioksidan. Ekstrak daun kirinyuh dibuat dalam bentuk sediaan submikro partikel untuk menstabilkan flavonoid yang terkandung di dalamnya…
Preparasi ekstrak etanol daun kirinyuh ke dalam submikro partikel bertujuan untuk mengatasi permasalahan sifat senyawa flavonoid yang terkandung didalam ekstrak yaitu termolabil serta meningkatkan kemampuan penghantaran pada kulit. Diperoleh kadar flavonoid total yang terkandung dalam ekstrak sebesar 95,204±3,568 mg/g. Metode emulsion solvent evaporation digunakan dalam preparasi ekstrak yang …
The leaves of cempedak (Artocarpus champeden) contain secondary metabolites in the form of flavonoid compounds which can be potential hepatoprotectors. This study aims to determine the effect of giving cempedak (Artocarpus champeden) leaf ethanol extract on the histopathological image of the liver of male white rats induced by carbon tetrachloride (CCl4) based on measurement parameters of SGPT …
Uji toksisitas subkronis kombinasi fraksi n-heksana dan etil asetat daun Karamunting (Rhodomyrtus tomentosa) pada tikus putih jantan dilakukan untuk mengetahui keamanan setelah pemberian sediaan uji secara berulang. Uji toksisitas kombinasi fraksi daun karamunting dilakukan selama 28 hari pemberian sediaan uji dan ditambah 14 hari untuk pengamatan efek yang tertunda pada tikus. Ada 4 kelompok m…
Salbutamol Sulfat memiliki waktu paruh yang relatif pendek dan bioavailabilitas yang rendah, apabila diberikan secara oral bioavailabilitas sistemiknya hanya 50% karena mengalami metabolisme lintas pertama di hati. Permeabilitas yang rendah akan mempengaruhi bioavaibilitas dari suatu obat maka dari itu perlu dilakukan modifikasi secara preparasi dan karakterisasi terhadap Salbutamol Sulfat menj…
Penumpukan radikal bebas yang berlangsung terus menerus dapat dihambat dengan adanya aktivitas antioksidan. Salah tanaman yang memiliki aktivitas sebagai sumber antioksidan alami berupa daun cempedak (Arthocarpus champeden (Lour.) Stokes). Kandungan senyawa flavonoid yang terdapat pada daun cempedak secara in vitro memiliki daya antioksidan yang sangat kuat dengan IC50 DPPH sebesar 8,88 mg/L. P…
Free radicals can cause oxidative stress, due to an imbalance between oxidants and antioxidants that have the potential to cause cell damage. The results of phytochemical screening showed that the ethyl acetate fraction of purple sweet potato leaves contained secondary metabolites such as flavonoids and tannins which have antioxidant properties. The purpose of this study was to determine the ch…
Biji cempedak (Arthocarpus champeden (Lour.) Stokes) mengandung flavonoid yang berpotensi memiliki aktivitas antioksidan dan perlu dibuktikan aktivitasnya serta perlu diketahui karakteristiknya. Karakteristik ekstrak etanol biji cempedak secara organoleptik bersifat ekstrak kental berwarna coklat kehitaman, berbau aromatik serta berasa pahit. Kadar sari larut air 39± 0,005%; kadar sari larut e…
Antidiabetic activity test of ethanolic extract coffee robusta‟s leaves (Coffea canephora) to rats induced by alloxan has been done. Male wistar albino rats are used as animal models which divided into 6 groups, normal group (aquadest), negative control group (Na CMC 0,5%), positive control group (glibenclamide 0,43 mg/200 gBB), and 3 test group (ethanolic extract of coffee robusta‟s leave …
Migration analysis of phthalate from plastic food packaging on food simulants using gas chromatography flame ionization detector (GC-FID) was studied. Phthalates are used in plastic as a plasticizer to improve flexibility. Phthalate derivatives such as di- 2-ethylhexyl phthalate (DEHP) have been used plastics. DEHP can migrate into the food because of the temperature and the length of time in c…