Oxidative stress caused by free radicals can cause significant disorders and contribute to the emergence of various chronic disease. The negative impact of these free radicals can be minimized by the use of antioxidants, such as the elephant lempuyang rhizome, which is often used as a medicinal plant and is believed to have antioxidant properties. This study aims to determine the antioxidant ca…
Coronary heart disease (CHD) is a chronic condition that requires long-term therapy, in which treatment adherence plays a crucial role in achieving optimal therapeutic outcomes. Low adherence among CHD patients is often associated with low self-efficacy, which may be influenced by inadequate health education. This study aimed to analyze the effect of leaflet-based education on therapy adherence…
The rhizome of Acorus calamus L. (Dlingo) is a plant known to contain various secondary metabolites with potential natural antioxidant properties. This study aimed to evaluate the antioxidant activity of the ethanolic extract of A. calamus L. rhizome, determine the fraction exhibiting the highest antioxidant activity based on IC₅₀ values obtained from the DPPH assay, and identify compounds …
Pharmaceutical management plays an important role in maintaining service quality, which has a direct impact on patient satisfaction, particularly among BPJS participants who routinely utilize hospital services. Based on pharmaceutical management principles that emphasize the effectiveness of medication provision and service delivery, this study aims to examine how the quality of outpatient phar…
The stem bark of breadfruit is known to contain bioactive compounds in the from flavonoids, which have antioxidant and anti inflammatory activities. These compounds have the potential to help reduce oxidative stress and inflammation in kidneys that experience demage due to exposure to nephrotoxic agents. This study aims to evaluate the activity of the ethanol extract of breadfruit stem bark (EE…
The bark of breadfruit (Artocarpus altilis) contains secondary metabolites such as flavonoids and phenolics that have antioxidant potential. This study aimed to determine the effect of breadfruit bark ethanol extract (EEKBS) on Wistar rats induced with gentamicin and piroxicam, causing oxidative stress. A total of 30 test animals were divided into 6 treatment groups, namely the normal group (Na…
Low back pain (LBP) is one of commonly encountered musculoskeletal disorders and may lead to physical function limitations and decreased quality of life. Pharmacological therapy commonly used in the management of LBP includes combinations of non-steroidal anti-inflammatory drugs (NSAIDs) with Paracetamol or muscle relaxants as adjuvant therapy. This study aimed to analyze the differences in phy…
Anemia in adolescent girls is a public health problem that impacts growth, learning ability, and future productivity. The government implements a Iron Tablet (TTD) supplementation program as an effort to prevent anemia. This study aims to cover the management of iron tablet planning and procurement for adolescent girls in two areas with different characteristics, namely the 4 Ulu Community Heal…
Pharmaceutical services are a critical component in ensuring the quality of hospital healthcare delivery. Waiting times that meet service standards reflect the efficiency of service processes as well as the performance of supporting systems, including human resources and information technology. This study aimed to comprehensively analyze barriers to service waiting times in the Outpatient Pharm…
Synthetic anti-inflammatory drugs are associated with the risk of serious adverse effects, highlighting the need for safer alternatives. Pepper elder (Peperomia pellucida L.) has been reported to exhibit anti-inflammatory activity in male rats; however, studies in female rats and data regarding its safety remain limited. This study aimed to evaluate the anti-inflammatory activity in female Wist…
Typhoid fever is a common infectious disease in Indonesia and may lead to serious complications if not managed appropriately. This study aimed to evaluate the rationality of drug therapy in hospitalized typhoid fever patients based on eight parameters of appropriateness. This research employed a prospective descriptive analytical design. Data were obtained from patients’ medical records and d…
Acute Respiratory Infection (ARI) is one of the most common diseases encountered among adult patients in healthcare facilities. This study aims to evaluate drug prescribing patterns and analyze their compliance with the Ministry of Health of the Republic of Indonesia's therapy guidelines for adult ARI patients at the Sukarami Public Health Center (Puskesmas) in Palembang. This study employed a …
Ethanol extract of breadfruit (Artocarpus altilis) stem bark is known to contain flavonoid compounds suspected to have potential as an antidepressant agent. This study was conducted to determine the effect and optimal concentration of the ethanol extract of breandruit stem bark for depression treatment. The test animals were divided into six groups: normal group (Na-CMC), negative group (Na-CMC…
The number of diabetes mellitus cases continues to increase each year. Antidiabetic drugs are essential for individuals with diabetes, particularly type 2, to control blood glucose levels. However, commonly used modern antidiabetic drugs are often associated with adverse side effects. Therefore, natural products such as karamunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) have been investi…
In this study, a deteriorating inventory model of pharmaceutical goods with a demand level using a cosine function that considers the storage level is developed. The mathematical model formulation in this research is assisted by WolframAlpha software while the numerical calculation uses the help of Google Colab software. The results showed that the sensitivity analysis carried out affected the …
Diabetes melitus is a chronic disease with a steadily increasing global prevalence, posing a significant concern in public health. This metabolic disorder is characterized by elevated blood glucose levels, which may lead to long-term complications if not managed properly. Conventional pharmacological therapies are commonly used to regulate glucose levels, but long-term use carries a risk of ser…
Sun exposure can cause damage to the skin due to ultra violet (UV) radiation. Excessive and prolonged exposure to sunlight can damage the skin layer and can cause negative health effects Additional protection is needed to reduce the transmission of UV rays to the skin and is known as a sunscreen agent. Samak leaf (Syzygium urceolatum (Korth.) Merr. & L.M.Perry) has the potential as a sunscreen …
Hypertension provides a major risk factor for cardiovascular and kidney disease. One of a therapy that used to treat a hypertension is diuretics. Gamal (Gliricidia sepium)contains flavonoid compounds which have diuretic effect. This study aims to determined activity of ethyl acetate fraction of gamal leaves as diuretic by measuring urine volume output and Na⁺, Cl⁻, dan K⁺ ion contents. Th…
National injury prevalence tends to increase every year. Wounds must be healed immediately because they are an important role in maintaining homeostasis and have the potential to become chronic infections if not treated. Cassava leaves (Manihot esculenta) contain the main substance rutin or quercetin 3-O-rutinoside (flavonoids) and contain saponins and tannins as anti-inflammatory, antibacteria…
Kidney stone disease (antinefrolithiasis) of calcium stone type is one of the health problems among Indonesian people. The use of diuretic drugs as a treatment for kidney stones can be replaced with natural ingredients to reduce the risk of side effects. Kersen leaves (Muntingia calabura L.) contain a lot of flavanes, flavones, flavanones, flavonols, and chalcones which are included in the flav…
Kidney stone disease (antinefrolithiasis) of calcium stone type is one of the health problems among Indonesian people. The use of diuretic drugs as a treatment for kidney stones can be replaced with natural ingredients to reduce the risk of side effects. Kersen leaves (Muntingia calabura L.) contain a lot of flavanes, flavones, flavanones, flavonols, and chalcones which are included in the flav…
Kecombrang flower (Etlingera elatior) contains various secondary metabolite compounds, one of which is flavonoids that have antioxidant activity. Orally Dissolving Film (ODF) was formulated to cover the unpleasant taste of kecombrang flowers. Pullulan is used as a polymer due to its ease of solubility in water and has good film-forming properties. This study aims to determine the best formulati…
Thrombosis is a condition in which a blood clot (thrombus) forms in a blood vessel. Treatment involves antithrombotic agents such as anticoagulants, and researchers developed silver-magnetite nanoparticles (Ag-Fe₃O₄) using a green synthesis method using robusta coffee bean extract (Coffea canephora) containing chlorogenic acid as a natural reducing, stabilizing, and thrombolytic agent. The …
Thrombosis is a leading global cause of cardiovascular diseases. While anticoagulants, antiplatelet agents, and thrombolytic therapies are the standard clinical treatments, iron oxide nanoparticles offer an alternative approach due to their ability to accumulate at sites of inflammation, such as thrombi and atherosclerotic plaques. These nanoparticles can act as photothermal agents, absorbing l…
Thrombosis is a condition that occurs due to an imbalance in the hemostasis system characterized by the formation of a blood clot (thrombus) in the blood vessel wall so that it can cause ischemic stroke disease. The anti-thrombotic drugs commonly used are thrombolytics. These drugs contain fibrinolytic enzymes such as protease enzymes. Pineapple (Ananas comosus (L.) Merr) is known to have an an…
Thrombosis caused by blood clot formation can lead to serious complications. Conventional therapies carry a risk of bleeding, making photothermal therapy based on optical-magnetic nanoparticles such as AgNO₃ and Fe₃O₄ a safer alternative. These nanoparticles are synthesized via green synthesis using butterfly pea flower (Clitoria ternatea L.) extract, which contains flavonoids and anthocy…
Kecombrang flower (Etlingera elatior) are plant from the Zingiberaceae family which has potential as an antioxidant. Kecombrang flowers have a distinctive smell and sour taste. The orally dissolving film (ODF) formulation which uses a combination of HPMC polymer and maltodextrin was able to eliminate the unpleasant taste of kecombrang flowers. Orally dissolving film (ODF) preparations was made …
One of the special toxicity tests is the teratogenic test which is carried out to obtain information on the presence of fetal abnormalities that occur due to the administration of test preparations during the formation of fetal organs (organogenesis period) and to complete safety data from the melinjo plant. The doses given were 69.48, 104.22, 138.96 and 173.7 mg/kgBW. The administration of the…
Kersen leaves (Muntingia Calabura L) contain secondary metabolite compounds alkaloids, flavonoids and tanins. The use of herbal medicine during pregnancy needs to be considered because the drug can cross the placenta so that it can cause teratogenic effects on the fetus. Teratogenic toxicity research on the ethanol fraction of kersen leaves (Muntingia Calabura L) has been conducted to determine…
ABSTRAK Kulit pisang kepok, yang mengandung sejumlah senyawa metabolit sekunder seperti flavonoid, telah diketahui memiliki potensi sebagai agen antidiabetes. Penelitian ini bertujuan untuk mengevaluasi seberapa efektif fraksi etil asetat dari kulit pisang kepok dalam menurunkan kadar glukosa darah. Penelitian melibatkan pembagian tikus percobaan ke dalam enam kelompok: kelompok normal (mendapa…