Background: Sarcopenia is a progressive skeletal muscle disorder characterized by a decline in muscle strength, mass, and physical performance, leading to increased fall risks and reduced quality of life in the elderly. The pathogenesis is driven by "inflammaging," particularly elevated levels of Interleukin 6 (IL-6). Given the rising geriatric population in Palembang, early detection through c…
Background: As people age, the human body undergoes physiological changes, including a progressive reduce of skeletal muscle mass and strength, known as sarcopenia. The diagnosis of sarcopenia is based on calf circumference screening, also measurement of muscle mass, muscle strength, and physical performance. The primary factors contributing to sarcopenia are systemic inflammation and oxidative…
Background: Pediatric intensive care unit (PICU) patients are in critical condition, requiring a clear understanding of admission indications, treatment priorities, and patient outcomes. Mapping these profiles is important to describe case patterns in the PICU at Dr. Mohammad Hoesin General Hospital in Palembang and to serve as a basis for evaluating and improving service quality. Objective: To…
Background: Hypertensive disorders in pregnancy remain one of the leading causes of maternal and fetal morbidity and mortality worldwide. These conditions may result in serious complications such as preeclampsia, eclampsia, and fetal growth restriction. Calcium requirements increase significantly during the third trimester to support fetal bone mineralization, while calcium deficiency has been …
Background Elderly individuals represent a population with a high potential for a decline in the quantity and quality of skeletal muscles, a condition known as sarcopenia. Muscle quantity refers to the reduction in muscle mass, while muscle quality can be assessed through muscle strength and physical performance as age advances. Sarcopenia significantly reduces the ability to perform daily func…
Background: The presence of a malignant pleural effusion (MPE) indicates advanced stage in malignancy, which severely compromises in a poor prognosis. The LENT score has been developed as a prognostic tool for MPE, yet its association with pleural effusion progression and six-month survival has not been thoroughly evaluated, particularly in Indonesia. Methods: This prospective cohort study incl…
Background: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from impaired insulin secretion or insulin resistance, with chronic low-grade inflammation playing a role in its pathogenesis. Diacerein has anti-inflammatory effects and improves insulin sensitivity; however, clinical evidence in Indonesia remains limited. Objective: To evaluate the effect of adding diacere…
Background. Breast lymphoma is a blood malignancy that can be seen as a primary tumor (primary breast lymphoma/PBL) or a secondary manifestation of lymphoma that arises from different parts of the body. Although it is rarer than breast cancer (BC), it has a worse prognosis than BC. This study aims to determine the number of cases and distribution of characteristics of breast lymphoma at Dr. Moh…
Background: Free radicals are reactive compounds that can cause oxidative stress and are related to diseases in the oral cavity, such as periodontitis. Semendo arabica coffee is rich of tannins, flavonoids, and polyphenol compounds that can neutralize free radicals. Semendo arabica coffee extract was reported to have antioxidant activity, therefore in this study it was developed into a jelly ca…
Background: Pulmonary tuberculosis (TB) is a chronic contagious infection caused by Mycobacterium tuberculosis. Tuberculosis is a public health problem that has become a global challenge. Non-adherence to treatment is one of the biggest obstacles in treating TB in the world, and is the factor that contributes most to treatment failure. The aim of this research is to determine the level of educa…
Background: Acute Coronary Syndrome (ACS) is one of the leading causes of mortality and hospitalization due to cardiovascular disease. Variations in patient characteristics and the presence of metabolic risk factors may influence the occurrence and prognosis of ACS. Therefore, understanding the profile of ACS patient characteristics is essential as a basis for preventive planning and clinical s…
Background: STEMI is an acute condition caused by obstruction of blood flow to the heart, leading to cardiomyocyte necrosis. This process begins with the formation of atherosclerotic plaques that cause total occlusion of the coronary artery lumen, resulting in myocardial ischemia. When transmural ischemia lasts for 20–40 minutes, cardiomyocyte necrosis occurs. Methods: This study aimed to des…
Latar belakang: Angular Cheilitis merupakan suatu keadaan inflamasi akut atau kronik yang dapat terjadi di sekitar sudut mulut dan meluas ke kulit ditandai adanya kemerahan, retakan, rasa nyeri, dan tanda lainnya. Keadaan ini lebih sering terjadi pada anak – anak terutama pada anak panti asuhan yang disebabkan oleh berbagai faktor penyebab seperti defisiensi nutrisi terutama pada kondisi keku…
Background: Heat-cured acrylic resin is one of the commonly used dental materials for the manufacture of denture bases. Color stability in acrylic resins is one of the most important clinical signs of aging or material deterioration after a long period of use, which can affect aesthetics. Factors that can affect the color stability of heat-cured acrylic resin includes acidic foods/beverages. Pe…
Background: Type 2 Diabetes Mellitus (T2DM) was a chronic metabolic disease with an increasing prevalence, accompanied by hepatic complications such as Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD). The duration of T2DM affected the severity of metabolic disturbances, insulin resistance, and hepatic fat accumulation. However, data on the incidence of MAFLD at RSUP Dr. Mohammad …
Background. Low back pain (LBP) is one of the most common musculoskeletal complaints and can adversely affect physical function, quality of life, and patient productivity. Vitamin D deficiency, assessed through serum 25-hydroxyvitamin D (25-OH D) levels, plays a role in pain modulation, muscle function, and inflammatory responses, and is suspected to be associated with LBP occurrence. This stud…
Urothelial carcinoma is the most common malignancy of the urinary tract and exhibits a wide range of clinicopathological characteristics that influence prognosis and patient management. Local data regarding the clinicopathological characteristics of urothelial carcinoma in Palembang remain limited; therefore, this study was conducted to provide a more representative overview. This study was a d…
Background: Chronic Kidney Disease (CKD) is a progressive condition that requires long-term hemodialysis treatment. Hemodialysis results are greatly influenced by vascular access, especially Arteriovenous Shunt (AV Shunt) as permanent access and Double Lumen Catheter (CDL) as temporary access. The difference between the patient's characteristics and the clinical condition is often a factor in t…
Introduction: Neonatal sepsis is a clinical syndrome of systemic disease accompanied by bacteremia in infants within the first month of life. Neonatal sepsis is one of the main causes of morbidity and mortality, both in full-term and premature infants. Cases of neonatal sepsis in Indonesia are quite high, including in high-risk groups such as male infants. The purpose of this study was to deter…
Background: Bone marrow trephine biopsy is an essential diagnostic procedure for hematological diseases through assessment of morphology, fibrosis, cellularity, and tumor involvement. Since 2023, Dr. Mohammad Hoesin General Hospital Palembang has routinely performed bone marrow biopsies; however, clinicohistopathological data remain limited. This study aimed to describe the bone marrow clinicoh…
Background: Acute coronary syndrome (ACS) is a heart disorder characterized by the sudden decrease of blood supply to the heart due to the narrowing of the coronary blood vessels. Acute coronary syndrome is based on risk factors such as age, gender, and lifestye. An abnormal lipid profile due to an unhealthy lifestyle is also one of the risk factors of acute coronary syndrome. This study aims t…
Background: Coronary Artery Bypass Graft (CABG) is a myocardial revascularization procedure aimed at restoring blood flow to the heart in patients with coronary artery disease. Postoperative evaluation of functional capacity is important to assess the effectiveness of cardiac recovery, particularly during phase I of cardiac rehabilitation. The Six-Minute Walk Test (6MWT) is a simple and safe me…
Background: Short-term memory is a chemical process between neurons in processing and storing information in a small and short duration. Memorizing the Qur'an can induce neuroplasticity through the Long-term Potentiation (LTP) mechanism, thus strengthening synaptic connections that will implement in increasing memory acuity and brain intelligence. This study aims to determine relationship betwe…
Latar belakang: Resin komposit packable konvensional memiliki kandungan filler yang tinggi dengan kekuatan fleksural yang tinggi. Namun, resin komposit packable memiliki viskositas yang tinggi sehingga sulit mengisi kavitas yang kecil. Highly filled flowable composite merupakan generasi baru dari resin komposit flowable dengan kandungan filler yang lebih tinggi sehingga tidak hanya digunakan un…
Background: Sexual harassment is a serious and widespread human rights violation, encompassing physical, verbal, or psychological acts without the victim's consent, occurring in various contexts such as households, workplaces, and educational institutions. Its impact is severe, including depression and decreased quality of life. Among students, cases of sexual harassment continue to increase, e…
Cervical cancer is the fourth most common cancer in the world, with a total of 569,847 cases and 311,365 deaths in 2018. Cervical cancer ranks as the second-highest cause of death in women . This study aims to determine the prevalence , age distribution , and distribution of histopathology subtypes based on the World Health Organization 2014 classification , the location of metastasis, the rela…
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype, with 150,000 new cases yearly. Roughly 40% of patients who receive rituximab in addition to vincristine, cyclophosphamide, doxorubicin, and prednisone treatment have primary refractory disease or recurrence. Although the Ann Arbor stage could determine DLBCL prognosis, new biomarkers are needed to stratify patient pro…
Background: Sarcopenia is a condition characterized by a decrease in muscle mass accompanied by a reduction in muscle strength and/or physical performance, which frequently occurs in older adults and leads to an increased risk of falls, dependency, cognitive and cardiopulmonary function decline, lower quality of life, mortality, and high healthcare costs. Calf circumference is recommended as a …
Background: Morbus Hansen (MH), also known as leprosy, is a chronic infectious disease caused by Mycobacterium leprae that primarily affects the skin and peripheral nerves. Despite global elimination efforts, MH remains a public health problem in Indonesia. Histopathological examination plays an essential role in establishing the diagnosis and determining the disease spectrum. This study aimed …
Background: The eyelids in humans have a vital role in protecting the eyes from the external environment and foreign objects. The skin of the eyelids is not only the thinnest skin of the body but also the part that is often exposed to sunlight, in addition the eyelids are also the most sensitive part of the body, making it possible to contract benign or malignant tumors. This study purpose is t…