Soil-Transmitted Helminth (STH) infections are a public health problem in many developing countries, particularly in subtropical and tropical regions, including Indonesia. Intestinal parasite are among the most common infections affecting individuals with HIV due to compromised immune function. Accurate diagnostic methods are essential for proper detection of these infections. This study aimed …
Background: Hydroxyapatite (HA) is a bio ceramic material that is currently widely developed as a bone graft material. In humans, HA constitutes nearly 70% of the weight of bone and teeth. This material can be synthesized from calcium carbonate derived from various natural sources. Chicken eggshells contain approximately 90% calcium carbonate, which can be used as an alternative source for the …
Staphylococcus aureus infection remains a global health problem due to the increasing emergence of antimicrobial resistance, highlighting the need for alternative antibacterial agents derived from natural products. This study aimed to evaluate the antimicrobial effectiveness of ethanol extract of miana leaves (Coleus atropurpureus) against Staphylococcus aureus ATCC 25923 and to identify its bi…
Background: Spatial memory is a critical cognitive function mediated by the hippocampus. High-fat diets are known to impair hippocampal function through systemic and cellular mechanisms. Green tea and vitamin D₃ have demonstrated neuroprotective properties; however, evidence regarding their combined effects on hippocampal function under high-fat diet conditions remains limited. Objectives: To…
Kandidiasis vulvovaginal (KVV) merupakan infeksi pada mukosa vulva dan vaginal yang paling sering diakibatkan oleh jamur Candida albicans. Ekstrak etanol buah Morinda citrifolia memiliki kandungan metabolit sekunder seperti flavonoid, terpenoid dan tanin yang dapat menghambat pertumbuhan jamur dan meredakan peradangan. Penelitian ini ditujukan untuk menganalisis efektivitas ekstrak etanol buah …
Background: Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose metabolism due to insulin resistance and decreased pancreatic β-cell function. One of the key factors in glucose regulation is the expression of GLUT 2, a glucose transporter that functions as a glucose sensor. Although drugs such as pioglitazone can improve insulin sensitivity, they may cause long-term side effec…
Refluks laring faring merupakan refluks isi gaster dan duodenum ke regio laring dan faring serta menyebabkan perubahan terkait inflamasi pada regio tersebut. Sejauh ini belum terdapat model hewan yang diterima secara universal untuk memodelkan refluks laring faring. Penelitian ini bertujuan untuk menciptakan suatu model hewan tikus untuk penelitian terkait refluks laring faring sekaligus membuk…
Background : Prediabetes is an intermediate condition with a high risk of progressing to type 2 diabetes mellitus (T2DM). First-degree relatives of individuals with T2DM possess significant genetic and environmental susceptibility. Early detection using inflammatory biomarkers such as TNF-α, along with anthropometric parameters like body mass index (BMI) and waist circumference, is essential f…
Background: Type 2 Diabetes Mellitus (T2DM) is a global health problem with increasing prevalence. Individuals with a family history of T2DM, especially first-degree relatives, have a higher risk of developing the disease. Chronic inflammation and immune dysregulation are believed to play a role in T2DM pathogenesis. The Systemic Immune-Inflammation Index (SII) and High-sensitivity C-reactive P…
Introduction: Epilepsy is a manifestation of brain disorders that is associated with high morbidity. Decreased vitamin D levels and incidence of metabolic syndrome in patients receiving antiseizure medications (ASMs) have been reported. This study aimed to analyse the effect of vitamin D administration on changes in plasma levels of HOMA-IR, adiponectin, homocysteine, and hs-CRP as biomarkers o…
Type 2 diabetes mellitus (T2DM) is a major global health concern with an increasing prevalence each year. It is characterized by chronic hyperglycemia caused by insulin resistance and impaired insulin secretion. Genetic predisposition plays a key role, as individuals with a first-degree family history of T2DM are at higher risk of developing the disease. Vitamin D is known to influence immune r…
ABSTRAK PERBANDINGAN PROPORSI KEJADIAN APOPTOSIS, NEKROPTOSIS DAN PIROPTOSIS DALAM PROSES KEMATIAN SEL T CD4 DENGAN PENANDA CASPASE 3, RIPK3 DAN CASPASE 1 PADA PASIEN HIV/AIDS NAIF DI RS MOHAMMAD HOESIN PALEMBANG Latar Belakang: Penurunan jumlah sel T CD4 merupakan ciri khas infeksi HIV yang berkontribusi pada gangguan sistem imun dan perkembangan AIDS. Mekanisme kematian sel T CD4 melibatkan b…
Dillenia suffruticosa (L.) leaves, commonly known as "Simpur Air", possess therapeutic potential as an anti-hyperuricemic agent. The plant contains secondary metabolites such as alkaloids, terpenoids, flavonoids, and fatty acid esters, which have been shown to inhibit xanthine oxidase (XO), an enzyme associated with hyperuricemia. This study aimed to evaluate the XO inhibitory effect of the eth…
Penggunaan larvasida kimiawi konvensional secara terus menerus sebagai salah satu upaya penanggulangan DBD (demam berdarah dengue) akan meningkatkan resistensi populasi vektor sehingga membutuhkan dosis insektisida yang lebih tinggi serta menimbulkan efek toksik bagi manusia, hewan, dan lingkungan. Oleh karena itu diperlukan larvasida alternatif khususnya yang berbahan alami atau biolarvasida s…
Alcohol abuse is a global health problem that damages the brain, particularly the prefrontal cortex area, through increased inflammation and apoptosis mediated by Caspase-3. Lifestyle interventions such as calorie restriction (CR) and exercise have the potential to provide neuroprotective effects. This study aims to evaluate the effect of CR and exercise on Caspase-3 expression in the brains of…
Global alcohol consumption is expected to rise by 17% over the next 13 years, which could increase the risk of liver disease due to oxidative stress, inflammation, and the activation of caspase-3, a key protein of apoptosis. While caloric restriction (CR) and exercise are known to reduce oxidative stress and caspase-3 levels, research on their effects on liver cell apoptosis during alcohol expo…
Latar Belakang: Salep ekstrak daun pegagan mengandung senyawa-senyawa seperti Triterpenoid, alkaloid, flavonoid, saponin, tanin, dan fenol. Triterpenoidnya terdiri dari asiatic acid, madecassocide, dan asiaticocide. Asiaticocide berperan dalam proliferasi fibroblast, sintesis kolagen, neovaskularisasi, dan antibakteri terhadap Staphyllococcus aureus dan Eschericia colli. Tujuan penelitian ini u…
Latar Belakang: Ubi jalar ungu (Ipomoea batatas L.) mengandung pigmen antosianin yang berkhasiat sebagai antioksidan kuat. Penelitian ilmiah terkait pemanfaatan ubi jalar ungu sebagai pengobatan herbal sebagai hepatoprotektor masih terbatas. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak ubi jalar ungu dalam penurunan ekspresi Caspase-3 dan penilaian gambaran histopatologi jaring…
Background : Collagen gel provides a moist environment that supports wound healing after tooth extraction. Fish skin can be an alternative source of collagen because of amino acid components and biocompatibility equal with mammalian collagen. The purpose of this study was to determine the effectiveness of the application of Siamese catfish (Pangasius hypophthalmus) collagen gel on the number of…