Background: Semaglutide is a GLP-1 receptor agonist used as a therapy to improve glycemic control in patients with Type 2 Diabetes Mellitus. Although its use continues to increase globally, data regarding the utilization pattern of this drug in Indonesia, remains scarce. Objective: To determine the pattern of semaglutide use among T2DM patients at Siloam Sriwijaya Hospital Palembang from Januar…
Background: Diabetic foot ulcer is a serious complication of diabetes mellitus that can lead to amputation and increase morbidity and mortality rates. PEDIS (Perfusion, Extent, Depth, Infection, Sensation) Score is a classification system developed by the International Working Group on the Diabetic Foot (IWGDF) to assess the severity of diabetic foot ulcers and predict prognosis. This study aim…
Effectiveness of Resveratrol Addition in Endothelial Dysfunction and Metabolic Control in Type 2 DM Patients at dr. Mohammad Hoesin Hospital Palembang Rita Sriwulandari*, Yulianto Kusnadi*, Taufik Indrajaya**, Legiran*** *Endocrine Metabolic Diabetes Division, ** Cardiology Division Internal Medicine Section/ Faculty of Medicine Sriwijaya University Palembang *** Anatomy Section Faculty of Medi…
Background: Exogenous insulin therapy in Type 2 Diabetes Mellitus (T2DM) patients can trigger an immunological response in the form of Insulin Antibody (IA) formation. Theoretically, the presence of these antibodies potentially affects treatment efficacy and increases the daily insulin dose requirement due to a neutralizing effect. This study aimed to evaluate the correlation between Insulin An…
Background: Diabetes mellitus (DM) is a global health burden with a continuously rising prevalence. Indonesia ranks seventh among countries with the highest number of people living with diabetes, with an estimated 10.7 million patients in 2019. Poor sleep quality is one of the most prevalent comorbidities in patients with DM and has been shown to impair glycemic control. Despite growing evidenc…
Type 2 Diabetes Mellitus (T2DM) is one of the non-communicable diseases prioritized in basic health services. One of the government’s efforts to ensure these services is through the Minimum Service Standards (MSS) in the health sector. This study aimed to describe the coverage of MSS for Type 2 Diabetes Mellitus services at 42 community health centers in Palembang City during 2023-2024 and to…
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. The development of therapies based on natural products may serve as an alternative approach to minimize the adverse effects associated with synthetic drugs. Red shoot leaves (Syzygium myrtifolium Walp.) are known to contain bioactive compou…
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. Pelawan leaves are known to contain bioactive compounds, particularly flavonoids and phenolics, which may exhibit antihyperglycemic activity. This study aimed to characterize the ethyl acetate fraction of pelawan leaves, evaluate th…
Background: The use of biosimilar insulin glargine offers a more economical therapeutic alternative compared to the originator product in the management of Type 2 Diabetes Mellitus (T2DM). However, differences in manufacturing processes for biological products have the potential to trigger different immune responses, one of which is the formation of Insulin Antibodies (IA). This study aims to c…
Type 2 Diabetes Mellitus (T2DM) is a chronic disease that requires long-term management. Medication adherence plays an important role in glycemic control, as measured by HbA1c, and also affects patients’ quality of life. This study aimed to analyze the relationship between medication adherence and HbA1c levels as well as quality of life among patients with T2DM at RSUD Siti Fatimah Palembang.…
Elevated blood glucose levels in patients with Type 2 Diabetes Mellitus (T2DM) are a chronic health issue requiring effective and easily implementable management to prevent complications. According to data from the International Diabetes Federation, approximately 589 million adults will be living with T2DM by 2025, with this number projected to reach 853 million by 2050. One approach that can b…
Background: Acrochordon is a benign fibroepithelial skin tumor commonly found in intertriginous areas and thought to be associated with insulin resistance (IR). Hyperinsulinemia resulting from IR contributes to fibroblast and keratinocyte proliferation through activation of the insulin-like growth factor-1 signaling pathway. The homeostatic model assessment of insulin resistance (HOMA-IR) is a …
Latar Belakang; Prevalensi terjadinya defisiensi Vitamin D pada penderita luka kaki diabetes cukup tinggi. Defisiensi vitamin D dapat menyebabkan hambatan penyembuhan luka. Vitamin D berperan sebagai regulator proliferasi sel dan pengaturan inflamasi. Proliferasi dan perbaikan jaringan melibatkan peran matrix metalloproteinase-9 (MMP-9) dan tissue inhibitor matrix metalloproteinase-1 (TIMP-1) s…
Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from insulin resistance and pancreatic β-cell dysfunction. Limitations of conventional therapies, which may cause adverse effects, have encouraged the development of antidiabetic agents derived from natural products. Paliasa leaves (Kleinhovia hospita Linn.) are known to contain bioactive compound…
Type 2 diabetes is a chronic disease that requires early detection to reduce the risk of complications. This study aims to design a web-based prototype Clinical Decision Support System (CDSS) to predict diabetes risk using the XGBoost algorithm and improve interpretability through the SHAP method. The dataset used was obtained from Kaggle and consisted of approximately 100,000 records with eigh…
The prevalence of type 2 diabetes mellitus in adults continues to increase, but the relationship between age, anxiety levels, and quality of life still shows varying results. This study aims to determine the relationship between age and anxiety levels with the quality of life of type 2 diabetes mellitus patients. This study used a quantitative method with a correlational design. The sample cons…
Program Pengelolaan Penyakit Kronis (Prolanis) merupakan sistem pelayanan kesehatan dan pendekatan proaktif yang diimplementasikan secara terintegrasi untuk mencegah dan mengendalikan penyakit kronis, termasuk DM. Keberhasilan program Prolanis dan PRB sangat bergantung pada kepatuhan pasien dalam melakukan kunjungan ulang secara teratur untuk pemantauan kondisi kesehatan dan penyesuaian terapi …
Chayote leaves (Sechium edule (Jacq.) Swartz) contain secondary metabolites like flavonoids, tannins, and saponins acting as antidiabetic agents through beta-cell protection. This study aimed to determine the antidiabetic activity of the ethanolic extract of chayote leaves (EECL) and evaluate its effect on pancreatic histopathology in hyperglycemic male Wistar rats. Hyperglycemia was successful…
Background : Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood sugar levels caused by insulin resistance or impaired insulin secretion. The prevalence of type 2 diabetes mellitus continues to increase, especially in rural areas due to low public awareness and limited access to non-communicable disease control. Methods : This study used a case-control design …
Background: Diabetes Mellitus (DM) is a chronic disease that may lead to long-term complications, including cognitive impairment, particularly among the pre-elderly population. Glycemic control, measured by HbA1c, is a key component of DM management and is influenced, among other factors, by medication adherence. Good glycemic control may contribute to reducing the risk of cognitive impairment.…
Type II Diabetes Mellitus is a non-communicable disease closely associated with dietary patterns and physical activity. This study aims to determine the relationship between dietary patterns and physical activity with random blood glucose levels among Type II Diabetes Mellitus patients at Balai Agung Health Center, Sekayu. The study employed a quantitative method with a cross-sectional design. …
Background: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia resulting from impaired insulin secretion or insulin resistance, with chronic low-grade inflammation playing a role in its pathogenesis. Diacerein has anti-inflammatory effects and improves insulin sensitivity; however, clinical evidence in Indonesia remains limited. Objective: To evaluate the effect of adding diacere…
The ability to do Self Care Management in patients with type 2 DM is low due to poor family support. Many family members in today's era of progress who are busy with their work cause people with type 2 DM if there are problems that are not paid attention to and feel burdensome to the family because of the disease experienced. Doing Self Care Management is very important because it can improve t…
Diabetes melitus is a chronic disease with a steadily increasing global prevalence, posing a significant concern in public health. This metabolic disorder is characterized by elevated blood glucose levels, which may lead to long-term complications if not managed properly. Conventional pharmacological therapies are commonly used to regulate glucose levels, but long-term use carries a risk of ser…
Diabetic retinopathy (DR) is a major complication of diabetes mellitus, characterized by damage to the retinal blood vessels and a high risk of blindness, particularly among individuals of productive age. Early detection of DR is essential, as the disease often presents no noticeable symptoms in its initial stages but can progress to permanent vision impairment if left untreated. This study aim…
Background: Type 2 Diabetes Mellitus (T2DM) was a chronic metabolic disease with an increasing prevalence, accompanied by hepatic complications such as Metabolic Dysfunction–Associated Fatty Liver Disease (MAFLD). The duration of T2DM affected the severity of metabolic disturbances, insulin resistance, and hepatic fat accumulation. However, data on the incidence of MAFLD at RSUP Dr. Mohammad …
Diabetes Mellitus is a chronic disease that requires long-term management, one of which is through dietary compliance. However, dietary non-compliance remains a common problem among Diabetes Mellitus patients in various healthcare facilities, including Makrayu Community Health Center of Palembang. Nurses' therapeutic communication plays an important role in improving patient understanding and m…
Adolescents represent a critical target group for early prevention efforts, as lifestyle behaviors adopted during this developmental stage contribute significantly to the risk of non- communicable diseases in adulthood, including diabetes mellitus. Diabetes mellitus is a global health concern with a continuously increasing prevalence. Unhealthy lifestyle patterns combined with low levels of kno…
The highest number of cases of diabetes mellitus in Ogan Ilir District in 2021 is the Puskesmas Indralaya with 1602 cases. The RPPT standard is at least 5%. While the DM RPPT indicator at the Puskesmas Indralaya is 0.12%. The purpose of this study is to evaluate the DM chronic disease management program (Prolanis) using a systems approach (input, process, output). This research uses qualitative…
Background : Diabetes mellitus is a non-communicable disease with a high prevalence and is frequently accompanied by hypertension, which increases the risk of vascular complications and imposes a substantial burden on quality of life and healthcare costs. It is estimated that approximately 40–80% of patients with diabetes also have hypertension; therefore, identifying risk factors associated …