Purple sweet potato leaves (Ipomoea batatas L.) is one of the traditional medicinal plants that needs to know the safety level of its use, one of which is by subchronic toxicity test. This study was conducted to determine the toxic effects of the n-hexane fraction of I. batatas leaves on wistar male white rats. Parameters observed included body weight, hematological examination, blood biochemis…
Background: High colonization of Candida albicans in mouth can increase the risk of oral candidiasis. Duku peel (Lansium domesticum Corr.) has potential as antifungal material due to its terpenoid and phenolic content which can be extracted with n-hexane as solvent. The pupose of this study is to determine the antifungal activity of n-hexane extract of duku peel against Candida albicans. Method…
Research had been carried out on the making of the anti acne peel off gel mask using kaffir lime leaves ethanol extract as active ingredient. Maceration method was used to extract the crude extract. Concentrated crude extract’s chemical compound was determined using phytochemical analysis and GC-MS. Its antibacterial activity was tested against Staphylococcus aureus and Propionibacterium acne…
This study aims to determine the antioxidant activity of purple sweet potato leaf ethanol fraction against decreased levels of malondialdehyde (MDA) blood plasma and mouse pancreas in vivo by TBARS method. The ethanol fraction of purple sweet potato leaves is obtained using a multilevel maceration method using n-hexane solvent, ethyl acetate and ethanol 96%. The test animals were grouped into 6…
The aims of this study are to determine the antioxidant activity of purple sweet potato leaves in inhibiting lipid peroxidation of blood and pancreas in rats. The solvent used is n-hexane, which is non polar solvent. The test of antioxidant activity using TBARS method by measuring the levels of malondialdehyde (MDA) plasma and pancreas induced by alloxan 150 mg/kg BW. The test animals were grou…
Uji Aktivitas Hepatoprotektor Ekstrak Etanol Kulit Buah Cempedak (Artocarpus champeden) Terhadap Kerusakan Hati Pada Tikus Putih Jantan Galur Wistar Terinduksi CCl4 Peggy Yulianda Jurusan Farmasi FMIPA Universitas Sriwijaya Abstract Cempedak peel is one of the plants that has the potential to be a source of antioxidants as an antidote to free radicals. The skin of cempedak peel ethanol extract …
Flacourtia rukam is a plant that has been used traditionally, one of its benefits as a treatment for diarrhea and dysentry. The aims of this study to isolated secondary metabolites from the methanol fraction of rukam leaves and their antibacterial activity test against Salmonella typhi and Shigella dysentriae. This research was started by maseration method using solvent with increasing polarity…
Salmonella typhi is gram negative bacteria caused typhoid fever. Typhoid fever highest cases in development country in south asian and southeast asian included Indonesian. A.conyzoides in empiric is using as herbal plant for typhoid fever treatment in Indonesian.This experiment was conducted to evaluate antibacterial activity of ethanol extract A.conyzoides leaves on rats has been infected. Cru…
Antioksidan merupakan substansi yang diperlukan tubuh untuk menetralisir radikal bebas dan mencegah kerusakan yang ditimbulkan oleh radikal terhadap melanosit pada kulit. Ekstrak daun kirinyuh (Chromolaena odorata) mengandung flavonoid yang berpotensi sebagai antioksidan. Ekstrak daun kirinyuh dibuat dalam bentuk sediaan submikro partikel untuk menstabilkan flavonoid yang terkandung di dalamnya…
Preparasi ekstrak etanol daun kirinyuh ke dalam submikro partikel bertujuan untuk mengatasi permasalahan sifat senyawa flavonoid yang terkandung didalam ekstrak yaitu termolabil serta meningkatkan kemampuan penghantaran pada kulit. Diperoleh kadar flavonoid total yang terkandung dalam ekstrak sebesar 95,204±3,568 mg/g. Metode emulsion solvent evaporation digunakan dalam preparasi ekstrak yang …
The leaves of cempedak (Artocarpus champeden) contain secondary metabolites in the form of flavonoid compounds which can be potential hepatoprotectors. This study aims to determine the effect of giving cempedak (Artocarpus champeden) leaf ethanol extract on the histopathological image of the liver of male white rats induced by carbon tetrachloride (CCl4) based on measurement parameters of SGPT …
Uji toksisitas subkronis kombinasi fraksi n-heksana dan etil asetat daun Karamunting (Rhodomyrtus tomentosa) pada tikus putih jantan dilakukan untuk mengetahui keamanan setelah pemberian sediaan uji secara berulang. Uji toksisitas kombinasi fraksi daun karamunting dilakukan selama 28 hari pemberian sediaan uji dan ditambah 14 hari untuk pengamatan efek yang tertunda pada tikus. Ada 4 kelompok m…
Penumpukan radikal bebas yang berlangsung terus menerus dapat dihambat dengan adanya aktivitas antioksidan. Salah tanaman yang memiliki aktivitas sebagai sumber antioksidan alami berupa daun cempedak (Arthocarpus champeden (Lour.) Stokes). Kandungan senyawa flavonoid yang terdapat pada daun cempedak secara in vitro memiliki daya antioksidan yang sangat kuat dengan IC50 DPPH sebesar 8,88 mg/L. P…
Free radicals can cause oxidative stress, due to an imbalance between oxidants and antioxidants that have the potential to cause cell damage. The results of phytochemical screening showed that the ethyl acetate fraction of purple sweet potato leaves contained secondary metabolites such as flavonoids and tannins which have antioxidant properties. The purpose of this study was to determine the ch…
Biji cempedak (Arthocarpus champeden (Lour.) Stokes) mengandung flavonoid yang berpotensi memiliki aktivitas antioksidan dan perlu dibuktikan aktivitasnya serta perlu diketahui karakteristiknya. Karakteristik ekstrak etanol biji cempedak secara organoleptik bersifat ekstrak kental berwarna coklat kehitaman, berbau aromatik serta berasa pahit. Kadar sari larut air 39± 0,005%; kadar sari larut e…
Second degree burns are risk of infection, dehydration, and complications if not treated immediately. Cempedak’s (Artocarpus champeden (Lour.) Stokes.) leaves ethanol extract contained secondary metabolites such as flavonoids, steroids, saponins, phenolics and tannins that can accelerate the burn healing process. This research are aims to determine the potential of cempedak leaves ethanol ext…
Hydrocortisone acetate can overcome the anti-inflammatory effect very well, the delivery system of active substances needed can enter through the systemic. Etosomes have a high penetration rate through the skin which can improve drug delivery through the stratum corneum. Gel preparations were made using variations in the concentration of carbopol® 940 with components consisting of triethanolam…