Background: Wound healing is a complex biological process that progresses through the phases of inflammation, proliferation, and remodeling. Cung kediro (Solanum lycopersicum var. cerasiforme) contains lycopene, β–carotene, vitamin C, and flavonoids, which act as potent antioxidants and have the potential to accelerate epithelialization, angiogenesis, and keratinization. This study aimed to …
Introduction: Oxidative stress is an imbalance between free radicals and endogenous antioxidants that plays a role in the pathogenesis of various degenerative diseases. Natural antioxidants from plants, particularly those containing phenolic compounds and flavonoids, have become potential alternatives for the prevention of oxidative stress. Kersen mistletoe leaves contain various secondary meta…
Indonesia merupakan salah satu negara dengan kekayaan hayati terbesar di dunia yang memiliki lebih dari 30.000spesies tanaman tingkat tinggi. Hingga saat ini tercatat 7000 spesies tanaman telah diketahui khasiatnya namun kurang dari 300 tanaman telah diketahui bahan baku farmasi secara regular. Namun, isu besar yang menjadi pemikiran pemerintah Indonesia saat ini adalah bagaimana menjamin obat …
Pemakaian tanaman obat untuk mengatasi berbagai masalah kesehatansaat ini mulai kembali menjadi tren dalam masyarakat di berbagai belahan dunia. “Back to Nature” pun sudah familiar terutama di kalangan masyarakat perkotaan. Sangat tidak tepat membandingkan manakah yang lebih baikantara obat-obatan konvensional atau modern dengan obat tradisional. Cara kerja obat tradisional tidaklah cepat,…
Background: Staphylococcus aureus is a gram-positive bacterium that causes skin diseases, pneumonia, respiratory tract infections, nosocomial bacteremia and is resistant to antibiotics. The incidence of antibiotic-resistant Staphylococcus aureus is increasing. Binahong is a herbal plant that has many benefits, one of which is as an antibacterial. Methods: This study used an experimental design.…
Staphylococcus aureus is one of the most commonly exposed bacteria and causes infection in humans. Efforts that can be made in medicine are using antibiotics. The use of antibiotics has recently been irrational and has led to antibiotic resistance. Efforts that can be made to prevent resistance are using alternative medicine. Alternative medicine that can be used is plants. Avocado leaves are h…
Background. Shigellosis is a clinical condition caused by invasion of Shigella species in the epithelium lining the terminal ileum, colon and rectum. Efforts that can be made to treat shigellosis are using fluoroquinolone antibiotics. However, cases of resistance of patients infected by Shigella to fluoroquinolone antibiotics have been reported to have increased in the Southeast Asian. This stu…
Background: Hyperuricemia is describes a condition where serum uric acid levels increase above normal values. Hyperuricemia occurs due to increased production and excretion of uric acid in the kidneys. The first line of treatment for reducing uric acid levels is xanthine oxidase inhibitors, allupurinol and febuxostat. However, many people use traditional medicine derived from natural plants. On…
Background: Purple sweet potato (Ipomoea batatas L.) is some type of potatoes that commonly used as an alternative for rice. Eventhough purple sweet potato was known to had phytopharmacal potentials, there is still few scientific literatures about the using of purple sweet potato as a therapeutic choice for renal fibrosis. This study is aimed to measure the efficacy of purple sweet potato extra…
Staphylococcus aureus is one of the most common bacterial infections in humans and is the causative agent of many human infections including bacteremia and sepsis. The use of antibiotics is a way of management, but excessive use can increase resistance. This study aims to see the effectiveness of antibacterial growth of ethanol extract of Carica papaya L. flowers on the inhibition of S.aureus A…
This research constitutes an experimental analytic study conducted in vivo, employing two parameters. The investigation of total cholesterol levels was conducted using a pre-test and post-test design with a control group. Conversely, the study of hepatic histology utilized a post-test with a control group design. Thirty male mice were allocated into five groups: a negative control, an obesity c…
Background: Indonesia's biodiversity is one of the features of our country. There are many plants with various potentials and benefits, including for health. One plant that can be used as an alternative treatment is the cherry plant. The benefits of the cherry plant are due to the secondary metabolite compounds it contains which can inhibit xanthine oxidase enzyme. Mistletoe can have the same c…
Background. Kersen leaf extract has the effect of inhibiting the xanthine oxidase enzyme and cherry mistletoe leaves also have the same properties considering that they are hemiparasites with their host. This study aims to determine the effect of n-hexane extract from mistletoe cherry leaves on the xanthine oxidase enzyme. Method. This research is an in vitro experimental research. The samples …
KIN THAT IS EXPOSED TO EXCESSIVE SUN EXPOSURE CAN RESULT IN SEVERAL LOSSES THAT CAN DAMAGE THE SKIN INCLUDING PREMATURE AGING, SKIN DAMAGE BY ULTRAVIOLET RADIATION, AND SUNBURN OR BURNING REACTIONS. SUNSCREEN IS NEEDED TO PROTECT THE SKIN FROM DAMAGE CAUSED BY UV RAYS. ZINC OXIDE IS A PHYSICAL SUNSCREEN AGENT THAT IS OFTEN USED AS AN ACTIVE INGREDIENT IN SUNSCREEN PREPARATIONS. AVOCADO LEAVES H…
Daun sambiloto (Andrographis paniculata (Burm.f.) Nees) merupakan tanaman yang mengandung senyawa aktif seperti andrografolida (diterpenlactone), flavonoid, asam quinic, steroid, saponin, alkaloid dan tanin yang memiliki potensi sebagai antiinflamasi, antioksidan, antibakteri, dan mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengoptimasi Gelling Agent pada sediaan gel ekstrak sa…
Daun sukun (artocarpus altilis) dilaporkan memiliki kandungan flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi memperbaiki fungsi ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh variasi dosis terhadap efek nefroprotektif. Parameter yang diamati meliputi volume urin, pH urin, kreatinin serum, ureum serum, protein urin, klirens kreatinin, serta dilakukan …
Kenikir leaves has pharmacological activity as an antidiabetic because it contains flavonoid compounds in the form of quersetin which can become the α-glukosidase enzyme inhibitor so that excess blood glucose level can be lowered. The effectiveness and bioavailability of extracts tend to be low so that the formula in the form of nanosuspension is an option for improving the delivery system whi…
Soursop leaf and sapodilla leaf contain secondary metabolit is flavonoid which is antioxidant. The study aimed to the characteristic of the ethanol extract soursop leaf (Annona muricata L.) and sapodilla leaf (Manilkara zapota L.), total flavonoid contents, and antioxidant activity of combine ethanol extract soursoup leaf and sapodilla leaf using DPPH method. The treatment of antioxidant activi…
Ekstrak etil asetat daun nangka (Artocarpus heterophyllus) mengandung senyawa metabolit sekunder berupa flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi memperbaiki fungsi ginjal. Penelitian ini bertujuan mengetahui aktivitas perbaikan fungsi ginjal dari ekstrak etil asetat daun nangka (EEADN). Uji aktivitas perbaikan ginjal dilakukan selama 28 hari menggunakan 30…
Breadfruit leaves (Artocarpus altilis (Park.) Fosberg) contain flavonoids which have activity and have the potential to act as photoprotective agents because of their ability to absorb UV light. This study aims to determine the effect of variations in the formulation of breadfruit leaf ethyl acetate extract on the effect of activity tests as a sunscreen with Carbomer 940 and Triethanolamine as …
Exposure to direct sunlight for a long time can cause damage to the epidermal tissue of the skin which is a factor in the emergence of erythema and causes skin cancer. Sunscreen is a cosmetic product that functions to protect the skin from exposure to UV rays. Breadfruit leaves (Artocarpus altilis) are reported to contain antioxidant compounds which have the potential to be active ingredients f…
Sambiloto leaves extract (Andrographis paniculata (Burm.f.) Wall. Ex Ness) contains andrographolid and flavonoid main secondary metabolites which have potential as ultraviolet radiation protection and antioxidant activity as photoprotective agents. This research aims to determine the optimization of Tween 80 and Ethanol 96% concentrations to increase their photoprotective and stability. Optimiz…
Daun cempedak (Artocarpus champeden) mengandung metabolit sekunder berupa flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi dalam memperbaiki fungsi ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etil asetat daun cempedak (EEADC) terhadap volume dan pH urin, kadar kreatinin dan ureum serum, kadar protein urin, klirens kretinin dan gamb…
Catechins compounds in gambier leaves have an antioxidant effect. The purpose of this study is to determine the optimal results of gambir leaf extract and the characteristic of optimal gambier leaf extract. The extraction method used in the study was ultrasoundassisted extraction (UAE). Data analysis was carried out using software design expert 13 with factorial 23. Factors in the extraction pr…
Background: The failure of endodontic treatment is often caused by errors during elimination procedures of Gram-positive bacteria (Enterococcus faecalis) so that it is necessary to use irrigating solutions such as sodium hypochlorite (NaOCl) to eliminate it from the root canal. Prabumulih City’s pineapple leaves (Ananas comosus) are herbal plants that have antibacterial properties due to the …
Daun salam (Syzygium polyanthum [Wight.] Walp.) mempunyai banyak khasiat bagi tubuh, salah satu khasiatnya adalah untuk mengatasi penyakit degeneratif. Telah dilakukan penelitian aktivitas antioksidan dari fraksi etanol daun salam secara in vivo dengan mengukur kadar malondialdehid, aktivitas enzim katalase, makroskopik dan histopatologi hati tikus. Metabolit sekunder yang terdapat di dalam dau…