Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or action. The increasing global prevalence of diabetes has encouraged the development of alternative therapies derived from natural products that are safer and more affordable. Miracle fruit (Synsepalum dulcificum) is traditionally used by the Penesak tribe in Ogan Ilir, S…
Background: Oral inflammation remains a common health problem in Indonesia. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) as conventional therapy is effective; however, long-term use may cause various side effects. Therefore, safer natural-based alternative therapies are needed. Gambir (Uncaria gambir Roxb.) is known to contain catechin compounds with anti-inflammatory activity. Obje…
Justicia secunda is a medicinal plant containing bioactive compounds whose composition is influenced by environmental conditions and cultivation practices. This study aimed to identify the metabolite profile of cultivated J. secunda leaves and evaluate their potential bioactivities. Extraction was carried out using 70% ethanol through the ultrasonic-assisted extraction (UAE) method, followed by…
This study is motivated by the high incidence of diseases transmitted by Culex sp. mosquitoes and the increasing resistance to chemical larvicides, highlighting the need for environmentally friendly control alternatives; therefore, it aims to evaluate the larvicidal activity of ethanol extract from lime leaves (Citrus aurantiifolia), determine the effective concentration, and calculate the LCâ‚…
Type 2 diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to insulin resistance and impaired pancreatic β-cell function. Red shoot leaves (Syzygium myrtifolium Walp.) contain active compounds such as phenolics and flavonoids with antidiabetic potential. This study aims to determine the compound groups of the ethyl acetate fraction of red shoot leaves, the effect of it…
The rising prevalence of type 2 diabetes mellitus (T2DM) indicates that this disease remains a health issue that requires serious attention. The long-term use of conventional therapies such as metformin may lead to adverse effects; therefore, alternative therapies based on natural products are needed. Pelawan leaves (Tristaniopsis merguensis Griff.) are known to contain bioactive compounds, par…
This study aims to describe medicinal plants used by the people of the Besemah Clan (Semende Tribe, Sub Semende Darat) in Sindang Danau District, Ogan Komering Regency, South Ulu. This study uses a qualitative descriptive method which was carried out from November 2025 to March 2026. Data collection was carried out through field observation and interviews. Sampling was carried out purposively o…
Memory decline is a cognitive problem that can be triggered by oxidative stress due to free radical activity. Pearl grass (Hedyotis corymbosa L.) is known to contain flavonoids and phenolic acids that have the potential to restore memory through antioxidant and neuroprotective effects. This study aimed to determine the effect of ethanol extract of pearl grass on restore memory in Swiss Webster …
Penelitian ini bertujuan untuk menguji daya analgesik dari ekstrak kulit kopi robusta (Coffea canephora) pada mencit (Mus musculus L.) galur Sub Swiss Webster. Penggunaan kulit kopi robusta, yang sering dianggap sebagai limbah, sebagai sumber potensi obat tradisional perlu diselidiki lebih lanjut. Penelitian ini menggunakan metode geliat (writhing test) yang diinduksi oleh asam asetat 1% secara…
Daun srikaya (Annona squamosa L.) mengandung flavonoid, alkaloid, saponin, dan triterpenoid yang berpotensi menimbulkan efek sedatif. Penelitian ini bertujuan mengetahui pengaruh serta dosis efektif ekstrak etanol daun srikaya terhadap efek sedatif pada mencit jantan galur Swiss Webster. Penelitian menggunakan RAL dengan 25 ekor mencit yang dibagi menjadi 5 kelompok, yaitu kontrol negatif (Twee…
Temu ireng (Curcuma aeruginosa Roxb.) is a medicinal plant from the Zingiberaceae family that is widespread in South Asia and Southeast Asia and has been reported to have antibacterial, anticancer, and antioxidant activities, especially in the rhizome. However, information on the antioxidant and antibacterial activities of fraction and isolated compounds is still limited. This study aims to ass…
ABSTRACT : Lenglengan (Leucas lavandulifolia) belongs to the Lamiaceae family. L. lavandulifolia is traditionally used in the treatment of headaches, migraines, rheumatism, and diabetes. Information on the activity and chemical content of L. lavandulifolia stems is still limited. The purpose of this study was to determine the antioxidant activity and chemical content of the most active column f…
Rambutan peel (Nephelium lappaceum L.) is an organic waste that has the potential to be used as a source of natural antioxidants due to its high phenolic and flavonoid content. This study aims to determine the total phenolic and flavonoid content, antioxidant activity, and quality characteristics of rambutan peel tea. Rambutan peel samples were dried, ground, and brewed using hot water at 90 °…
Pelawan leaves (Tristaniopsis merguensis Griff.) are a plant that contain important secondary metabolites such as flavonoids, tannins, saponins, and phenolic compounds, which have potential roles in regulating lipid metabolism. This study aimed to evaluate the effect and effective dose of the ethanolic extract of pelawan leaves in reducing total cholesterol, Low Density Lipoprotein (LDL), and t…
Latar belakang: Aggregatibacter actinomycetemcomitans adalah bakteri gram negatif yang paling sering ditemukan pada periodontitis. Daun sirih merah sebagai bahan alami dilaporkan memiliki kandungan senyawa berupa flavonoid, alkaloid, tanin, saponin dan minyak atsiri yang terbukti memiliki efek antibakteri. Tujuan: Mengetahui ada atau tidaknya aktivitas antibakteri ekstrak daun sirih merah (Pipe…
Barringtonia acutangula or indian oak is a type of tree that are found in many swamps and river banks in Sumatera Selatan region. Determination of total phenolic content, total flavonoid content, antioxidant activity and toxicity of indian oak (Barringtonia acutangula) leaves extract was carried out. Extraction process was carried out by using increasing polarity maceration with n-hexane, ethyl…
Infections caused by antibiotic-resistant bacteria, particularly carbapenem-resistant Pseudomonas aeruginosa (CRPA), have become a significant global health issue. Pseudomonas aeruginosa is a common nosocomial pathogen that often demonstrates resistance to many antibiotics. Given the rising cases of antibiotic resistance, alternative treatments are needed, one of which involves utilizing the po…
One of the obstacles in tilapia cultivation is the Aeromonas hydrophila bacteria that causes Motile Aeromonas Septicemia (MAS) disease. This disease can be overcome by using natural ingredients. One of the natural ingredients that can be used to treat bacterial diseases in fish is the stem of brotowali (Tinospora crispa L.). The use of the stem of brotowali has been proven in vitro to inhibit A…
Sebuah ulasan tentang tanaman obat yang dipakai secara turun temurun untuk mengatasi tiga penyakit utama masyarakat dewasa yaitu diabetes, asam urat, dan tekanan darah tinggi. Penyakit-penyakit tersebut sangat banyak diderita masyarakat Indonesia dari kelas bawah sampai kelas atas. Beberapa keuntungan pemakaian obat tradisional dalam mengatasi masalah kesehatan adalah biaya yang lebih murah, ef…
Staphylococcus aureus infection is caused by a bacterium that colonizes various organs in the human body, particularly the upper respiratory tract, including the skin, nasal cavity, axilla, and inguinal area. The emergence of antibiotic-resistant S. aureus, known as MRSA and VRSA, presents a significant challenge in the treatment of such infections. Natural products, such as the torch ginger fl…
This study aims to determine the effect of the use of ethanol extract of temu mango rhizome (Curcuma mangga Val) on anti-inflammatory in mice (Mus musculus) Swiss Webster Strain. The method used is an experimental method with a completely randomized design (RAL) design consisting of 5 treatments and 6 replicates. The treatment consisted of one negative control group (Aquades), one positive cont…
This study aims to determine the effect of aqueous extract of Curcuma mangga Val. rhizome on the anti-inflammatory response in mice (Mus musculus). The study employs an experimental method with a completely randomized design (CRD) consisting of five treatment groups: a negative control (aqueous solution), a positive control (Sodium Diclofenac 0.13 mg/kgBW), and three doses of Curcuma mangga rhi…
flavonoid compounds and has the potential as an antihyperuricemia. This study aims to evaluate the antihyperuricemia activity of ethanol extract of B. spectabilis in male white rats of the Wistar strain. Extraction was carried out by the maceration method using 96% ethanol. The extract was characterized and tested the antihyperuricemia activity used 35 rats male were divided into 7 groups: norm…
Lawsonia inermis L. is one of the traditional medicinal plants that are effective as analgesics. The analgesic effect was related to the ability of the substance to reduced uric acid levels (antihyperuricemia). This study aims to determine the antihyperuricemia activity of ethanol extract of L. inermis leaves using male white rats of the Wistar strain induced in hyperuricemia condition. The stu…
The ethanol extract of seburo leaves (Garcinia forbesii King) contains flavonoid, alkaloid, phenolic, saponin and steroid compounds which are potentially active as an analgesic and anti-inflammatory. This study aims to determine the characteristics of the extract as well as the analgesic and anti-inflammatory effects of the ethanol extract and fractions with different solvent polarities from se…
The sungkai leaf (Peronema canescens jack.) is known to contain flavonoid compounds with potential diuretic properties. This study aimed to evaluate the diuretic activity of ethanolic extract from sungkai leaves through preclinical tests on experimental animals divided into six treatment groups. These groups consisted of a normal control (aquadest), a negative control (NaCMC), a positive contro…
The Kardia plant (Bellucia Pentamera Naudin), a member of the Melastomataceae family, contains compounds such as steroids, triterpenoids, and flavonoids, which exhibit potential analgesic and anti-inflammatory properties. This study aims to characterize the extract and evaluate its analgesic and anti-inflammatory effects based on the reduction in writhing behavior in mice and edema volume in ra…
Free radical that can cause damage to body cells by oxidative stress as a trigger factor for degenerative diseases with the presence of antioxidant compounds able to counteract free radical. Medical plants ciplukan, guajava, katuk, and cat’s whiskers are utilized as antihypertensive traditional medicine because their bioactive compounds support blood pressure control. This study was conducted…
Moringa leaf (Moringa oleifera L.) are proven to contain secondary metabolites, one of which is flavonoids in the form of quercetin which has the ability as an anticancer. This study aims to determine the optimum formula of nanoparticles from a variety of alginate chitosan coatings at concentrations of 0.3% and 0.6% conjugated with folic acid. Moringa leaf extract was obtained through maceratio…