Winged bean (Psophocarpus tetragonolobus (L.) DC) is known to contain various bioactive compounds with potential antidiabetic properties. This study aimed to determine the characteristics and antidiabetic activity of the ethanolic extract of winged bean leaves, as well as to evaluate pancreatic histopathological changes in hyperglycemic male Wistar rats. Type 2 diabetes mellitus was induced by …
A study has been conducted to evaluate the antihyperlipidemic activity of the ethanolic extract of winged bean leaves (Psophocarpus tetragonolobus (L.) DC) in male Wistar rats induced by a high-fat and fructose diet. Male Wistar rats were divided into six groups: normal group, positive control (simvastatin 0.9 mg/Kg BW), negative control (0.5% NaCMC), and three treatment groups receiving ethano…
Chayote leaves (Sechium edule (Jacq.) Swartz) contain secondary metabolites like flavonoids, tannins, and saponins acting as antidiabetic agents through beta-cell protection. This study aimed to determine the antidiabetic activity of the ethanolic extract of chayote leaves (EECL) and evaluate its effect on pancreatic histopathology in hyperglycemic male Wistar rats. Hyperglycemia was successful…
This study aimed to evaluate the antihyperlipidemic activity of the ethanolic extract of chayote leaves (Sechium edule (Jacq.) Swartz) in male Wistar rats induced with a high-fat and fructose diet. The induction was performed to establish a hyperlipidemic condition characterized by increased total cholesterol and LDL levels, along with decreased HDL levels. This study also assessed the effect o…
Excessive exposure to free radicals can trigger oxidative stress, which plays a role in damaging various cellular components, including lipids, proteins, and genetic material, thereby increasing the risk of degenerative diseases. One approach to inhibiting this process is the utilization of antioxidant compounds derived from natural sources. Dayak onion bulbs (Eleutherine bulbosa (Mill.) Urb.) …
Oxidative stress caused by free radicals can cause significant disorders and contribute to the emergence of various chronic disease. The negative impact of these free radicals can be minimized by the use of antioxidants, such as the elephant lempuyang rhizome, which is often used as a medicinal plant and is believed to have antioxidant properties. This study aims to determine the antioxidant ca…
Coronary heart disease (CHD) is a chronic condition that requires long-term therapy, in which treatment adherence plays a crucial role in achieving optimal therapeutic outcomes. Low adherence among CHD patients is often associated with low self-efficacy, which may be influenced by inadequate health education. This study aimed to analyze the effect of leaflet-based education on therapy adherence…
The rhizome of Acorus calamus L. (Dlingo) is a plant known to contain various secondary metabolites with potential natural antioxidant properties. This study aimed to evaluate the antioxidant activity of the ethanolic extract of A. calamus L. rhizome, determine the fraction exhibiting the highest antioxidant activity based on IC₅₀ values obtained from the DPPH assay, and identify compounds …
Pharmaceutical management plays an important role in maintaining service quality, which has a direct impact on patient satisfaction, particularly among BPJS participants who routinely utilize hospital services. Based on pharmaceutical management principles that emphasize the effectiveness of medication provision and service delivery, this study aims to examine how the quality of outpatient phar…
The stem bark of breadfruit is known to contain bioactive compounds in the from flavonoids, which have antioxidant and anti inflammatory activities. These compounds have the potential to help reduce oxidative stress and inflammation in kidneys that experience demage due to exposure to nephrotoxic agents. This study aims to evaluate the activity of the ethanol extract of breadfruit stem bark (EE…
The bark of breadfruit (Artocarpus altilis) contains secondary metabolites such as flavonoids and phenolics that have antioxidant potential. This study aimed to determine the effect of breadfruit bark ethanol extract (EEKBS) on Wistar rats induced with gentamicin and piroxicam, causing oxidative stress. A total of 30 test animals were divided into 6 treatment groups, namely the normal group (Na…
Low back pain (LBP) is one of commonly encountered musculoskeletal disorders and may lead to physical function limitations and decreased quality of life. Pharmacological therapy commonly used in the management of LBP includes combinations of non-steroidal anti-inflammatory drugs (NSAIDs) with Paracetamol or muscle relaxants as adjuvant therapy. This study aimed to analyze the differences in phy…
Synthetic anti-inflammatory drugs are associated with the risk of serious adverse effects, highlighting the need for safer alternatives. Pepper elder (Peperomia pellucida L.) has been reported to exhibit anti-inflammatory activity in male rats; however, studies in female rats and data regarding its safety remain limited. This study aimed to evaluate the anti-inflammatory activity in female Wist…
Typhoid fever is a common infectious disease in Indonesia and may lead to serious complications if not managed appropriately. This study aimed to evaluate the rationality of drug therapy in hospitalized typhoid fever patients based on eight parameters of appropriateness. This research employed a prospective descriptive analytical design. Data were obtained from patients’ medical records and d…
Acute Respiratory Infection (ARI) is one of the most common diseases encountered among adult patients in healthcare facilities. This study aims to evaluate drug prescribing patterns and analyze their compliance with the Ministry of Health of the Republic of Indonesia's therapy guidelines for adult ARI patients at the Sukarami Public Health Center (Puskesmas) in Palembang. This study employed a …
Ethanol extract of breadfruit (Artocarpus altilis) stem bark is known to contain flavonoid compounds suspected to have potential as an antidepressant agent. This study was conducted to determine the effect and optimal concentration of the ethanol extract of breandruit stem bark for depression treatment. The test animals were divided into six groups: normal group (Na-CMC), negative group (Na-CMC…
The number of diabetes mellitus cases continues to increase each year. Antidiabetic drugs are essential for individuals with diabetes, particularly type 2, to control blood glucose levels. However, commonly used modern antidiabetic drugs are often associated with adverse side effects. Therefore, natural products such as karamunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) have been investi…
Diabetes melitus is a chronic disease with a steadily increasing global prevalence, posing a significant concern in public health. This metabolic disorder is characterized by elevated blood glucose levels, which may lead to long-term complications if not managed properly. Conventional pharmacological therapies are commonly used to regulate glucose levels, but long-term use carries a risk of ser…
Thrombosis is a condition in which a blood clot (thrombus) forms in a blood vessel. Treatment involves antithrombotic agents such as anticoagulants, and researchers developed silver-magnetite nanoparticles (Ag-Fe₃O₄) using a green synthesis method using robusta coffee bean extract (Coffea canephora) containing chlorogenic acid as a natural reducing, stabilizing, and thrombolytic agent. The …
Thrombosis is a leading global cause of cardiovascular diseases. While anticoagulants, antiplatelet agents, and thrombolytic therapies are the standard clinical treatments, iron oxide nanoparticles offer an alternative approach due to their ability to accumulate at sites of inflammation, such as thrombi and atherosclerotic plaques. These nanoparticles can act as photothermal agents, absorbing l…
Thrombosis is a condition that occurs due to an imbalance in the hemostasis system characterized by the formation of a blood clot (thrombus) in the blood vessel wall so that it can cause ischemic stroke disease. The anti-thrombotic drugs commonly used are thrombolytics. These drugs contain fibrinolytic enzymes such as protease enzymes. Pineapple (Ananas comosus (L.) Merr) is known to have an an…
Thrombosis caused by blood clot formation can lead to serious complications. Conventional therapies carry a risk of bleeding, making photothermal therapy based on optical-magnetic nanoparticles such as AgNO₃ and Fe₃O₄ a safer alternative. These nanoparticles are synthesized via green synthesis using butterfly pea flower (Clitoria ternatea L.) extract, which contains flavonoids and anthocy…
One of the special toxicity tests is the teratogenic test which is carried out to obtain information on the presence of fetal abnormalities that occur due to the administration of test preparations during the formation of fetal organs (organogenesis period) and to complete safety data from the melinjo plant. The doses given were 69.48, 104.22, 138.96 and 173.7 mg/kgBW. The administration of the…
Kersen leaves (Muntingia Calabura L) contain secondary metabolite compounds alkaloids, flavonoids and tanins. The use of herbal medicine during pregnancy needs to be considered because the drug can cross the placenta so that it can cause teratogenic effects on the fetus. Teratogenic toxicity research on the ethanol fraction of kersen leaves (Muntingia Calabura L) has been conducted to determine…
Acne is a condition characterized by the accumulation of sebum from sebaceous glands in the skin layers, which often stimulates the growth of acne-causing bacteria, such as Staphylococcus aureus. Acne treatment can be performed using acne patches; however, commercial acne patches are only capable of absorbing sebum without providing antibacterial activity. This study aimed to enhance therapeuti…
Bunga kecombrang (Etlingera elatior) dikenal sebagai bunga khas Asia tenggara famili Zingiberaceae dengan warna merah menyala dan bau khas. Pemanfaatan sediaan orally dissolving film (ODF) dapat menetralisir rasa asam pada bunga kecombrang. Variasi konsentrasi ekstrak etanol bunga kecombrang 0,5%, 0,6%, 0,7%. Evalusi sediaan untuk menentukan formula terbaik meliputi organoleptis, ketebalan, bob…
Essential oil is one of the non-oil and gas export commodities, gambir is one of the sap-producing plants used for industrial and pharmaceutical purposes, how much gambir essential oil and yield obtained and what components are contained in gambir essential oil, and how much yield is obtained, knowing the components contained in gambir essential oil (Uncaria Gambir Roxb), the research method us…
Hyperlipidemia is a metabolic disorder that acts as a major risk factor for cardiovascular disease. This condition is often accompanied by various complications such as hypertension, diabetes mellitus, and ischemic heart disease, which causes higher complexity of therapy. The complexity of treatment in hyperlipidemia patients increases the potential for Drug-Related Problems (DRPs), which can a…
This study aims to evaluate the potential of ethanol extract of putat leaves (Barringtonia acutangula) in stimulating the growth of probiotic Bifidobacterium longum and test its ability to inhibit the growth of pathogenic Escherichia coli bacteria. Bifidobacterium longum is one of the lactic acid bacteria that are beneficial for human gut health, while E. coli bacteria are known as opportunisti…
Diarrhea caused by Escherichia coli infections remains a significant public health problem in developing countries, including Indonesia. Overuse of antibiotics can lead to resistance, so alternatives are needed. Putat leaves (Barringtonia acutangula) contain the flavonoid quercetin, which has prebiotic and antibacterial potential. This study aims to investigate the effect of putat leaf extract …