Chinese betel leaf (peperomia pellucida) contains secondary metabolite compounds such as flavonoids and terpenoids that have potential as antioxidants. This study aims to determine the effect of giving extracts and fractions of Chinese betel herb invivo on male Wistar rats induced oxidative stress by carbon tetrachloride (CCl4). The 30 test animals were divided into 6 treatment groups, namely t…
Acacia leaves (Acacia Mangium Wild) contain secondary metabolite compounds of flavonoids in the form of quercetin which have the potential as antidepressants. This study aims to determine the effect of giving ethanol extract of acacia leaves and its effective dose on antidepressant activity. This study used 30 test animals which were divided into 6 groups, namely, the normal group (1 NaCMC with…
Pharmaceutical services are an important aspect of health facilities that directly affect patient satisfaction, one such service is prescription services. Patients often complain about waiting time for prescription services because it impacts their experience obtaining health services. The objective of this study evaluates how waiting time towards prescription services affects outpatient satisf…
Staphylococcus aureus infection is caused by a bacterium that colonizes various organs in the human body, particularly the upper respiratory tract, including the skin, nasal cavity, axilla, and inguinal area. The emergence of antibiotic-resistant S. aureus, known as MRSA and VRSA, presents a significant challenge in the treatment of such infections. Natural products, such as the torch ginger fl…
Daun kencana ungu (Ruellia tuberosa L.) merupakan salah satu tanaman yang dimanfaatkan secara luas sebagai obat tradisional. Daun kencana ungu memiliki aktivitas farmakologis sebagai antihiperglikemia, antidiabetes, dan antihipertensi. Penelitian ini dilakukan dengan tujuan untuk mengetahui toksisitas subkronis ekstrak etanol daun kencana ungu terhadap tikus putih jantan galur Wistar. Pada pene…
Paliasa (Kleinhovia hospita L.) belongs to Malvaceae family with high potential as a medicinal plant because it contains flavonoids,tannins,saponins, steroids and phenolic compounds. This study aims to measure total phenolic content and antioxidant power in extracts and fractions of stem bark, leaves, and root bark of Paliasa and the correlation between antioxidant and total phenolic. Testing t…
Daun singkong (Manihot esculenta Crantz.) terbukti sebagai antibakteri karena kandungan senyawa rutin yang tinggi. Transfersom mampu berpenetrasi melintasi stratum korneum untuk meningkatkan efek antibakteri senyawa rutin pada fraksi etil asetat daun singkong dengan hidrofilisitasnya. Penelitian ini bertujuan untuk mengoptimalkan formula transfersom fraksi etil asetat daun singkong dengan varia…
Transdermal patch was chosen to manage the delivery system of the antibacterial compound in cassava leaves, which is rutin, that is hydrophilic. Plasticizer is one of the additional ingredients of transdermal patches that can maintain the bioavailability of a drug. Transdermal patch formulation with active cassava leaf ethyl acetate fraction ingredients and 3 variations of PEG-400 concentration…
Free radicals are dangerous because they can cause degenerative disease. Free radicals can be neutralized by antioxidants. Plants that has potential as an antioxidant is gelam (Melaleuca leucadendra (L.) L.). Gelam leaves contain phenolics, flavonoids, steroids, triterpenoids, tannins, and saponins that have pharmacological activity as antioxidants. The study aimed to determine the characterist…
Ibuprofen is included in the Biopharmaceutical Classification System (BCS) Class II, namely drugs with irregular, slow and incomplete absorption properties. The combination of chitosan polymer with sodium alginate will increase the solubility of ibuprofen without causing systemic toxicity. Making a solid dispersion of ibuprofen using the co-grinding technique is carried out with the aim of redu…
A stroke is a nerve funcion that results from a blockage caused by blood clots and causes the oxygen and nutrients in the brain to suffer tissue damage. This study uses the Naïve Bayes and Fuzzy Naïve Bayes method based on Repeated Split Validation Resampling and variable selection use Chi square to classify stroke disease. The data used on this research is a Stroke Prediction Dataset from Ka…
Harendong Bulu (Miconia crenata (Vahl) Michelang.) contains secondary metabolites including flavonoids, saponins, tannins, steroids, triterpenoids, and phenolics. Phenolic compounds contained in harendong bulu are known to have antioxidant power. The purpose of this study was to measure total phenolic content and antioxidant power of extracts and fractions from stems, leaves, and roots of haren…
Acne vulgaris is often a skin problem that can be caused by the bacteria Propionibacterium acnes. A natural ingredient that can inhibit the growth of P. acnes bacteria is Thymoquinone which is contained in black cumin oil. A combination of HPMC as a gelling agent and black cumin oil as an anti-acne with 3 kinds of formulas with different concentrations of HPMC and black cumin. The aim of this r…
Bedah sesar (Sectio Caesarea) adalah suatu tindakan medis untuk melahirkan seorang bayi dengan cara penyatan pada dinding abdomen dan uterus wanita. Pemberian antibiotik profilaksis dapat mencegah terjadinya infeksi luka operasi (ILO) dan pemberian analgesik dapat mengurangi rasa nyeri yang dirasakan paska bedah sesar. Apabila tidak diberikan antibiotik dan analgesik besar resiko persalinan bed…
Diare merupakan salah satu masalah kesehatan global termasuk di Indonesia, khususnya pada anak. Pada tahun (2017) World Health Organization mencatat bahwa sekitar 1,7 milliar anak balita meninggal setiap tahunnya karena diare di seluruh dunia. Tujuan dari penelitian ini adalah mengevaluasi penggunaan antibiotik secara kuantitatif dan kualitatif. Penelitian ini merupakan penelitian prospektif ya…
The flavonoid content in melinjo leaves (Gnetum gnemon L.) has the potential to dissolve kidney stones through increased urinary citrate excretion, diuresis, and antioxidant effects. This study aims to examine the kidney stone dissolving activity of ethyl acetate fraction of melinjo leaves (FEADM) through urine pH, serum creatinine, ureum and kidney calcium levels, macroscopic and histopatholog…
Kepok banana peel (Musa balbisiana Colla) is known to contain flavonoid secondary metabolites which have antidiabetic effects. The purpose of this research was to determine the effectiveness of reducing blood glucose levels in the ethanol fraction of Kepok banana peel. This study was divided into 6 groups, namely the normal group (0.5% Na-CMC suspension), positive control (Metformin 9mg/200g), …
Erythromycin has the properties of a macrolide derivative antibiotic, but erythromycin has the disadvantage that it is not soluble in water. One way to increase the solubility of erythromycin is through a solid dispersion system. The solid dispersion that has been made is then formulated into a gel preparation with the aim of inserting erythromycin through the skin pores. The gel base used is H…
This research aims to increase the solubility of seaweed extract (sargassum sp) in sunscreen formulations using ionic gelation nanoparticles. determine the resulting characteristics including particle diameter, PDI, and zeta potential. This research begins with the seaweed process to make alginate, make ionic gelation nanoparticles and make sunscreen cream preparations. The ionic gelation metho…
Sunscreen memiliki manfaat bagi kulit manusia yaitu melindung kulit dari paparan sinar matahari dimana vitamin D yang dibutuhkan oleh manusia dan bersumber dari sinar matahari tetapi akibat penipisan lapisan ozon, sinar matahari yang berbahaya menembus ke kulit manusia yang berdampak negatif jika terpapar terlalu lama. Penelitian ini dilakukan untuk mengetahui peningkatan stabilitas dan penetra…
Daun kencana ungu (Ruellia tuberosa L.) merupakan salah satu obat herbal yang dapat menyembuhkan berbagai penyakit. Daun kencana ungu diketahui mengandung senyawa metabolit sekunder seperti alkaloid, flavonoid, triterpenoid, steroid dan saponin. Tujuan penelitian ini untuk mengetahui efektivitas penurunan kadar glukosa darah fraksi N-Heksan daun kencana ungu. Penelitian ini dibagi menjadi 6 kel…
Kencana Ungu (Ruellia tuberosa L.) is one of the natural plant that contain secondary metabolite such as flavonoid, triterphenoid, polyphenol which has the antidiabetic activity. The purpose of this study is to determine the results of phytochemical screening, total flavonoid content, %PKGD value, effective dose (ED50) and pancreatic histopathological profiles of the ethanol extract of kencana …
Boroco plant (Celosia argentea L.) is a plant that has antioxidant properties, which contains phytochemical components such as phenols, flavonoids, saponins, alkaloids and tannins that have antioxidant properties. This study aims to measure the antioxidant power and total phenolic content in extracts and fractions from boroco stems, leaves and seeds and to determine the correlation between anti…
The Bandotan plant (Ageratum conyzoides L.) is classified as a seasonal herb weed which contains secondary metabolites including terpenes, sterols, flavonoids, alkaloids, benzofuran, chromen, chromone, coumarin, essential oils and tannins so that it has antioxidant activity. This study aims to measure the total phenolic content and antioxidant power of ethanol extract, n-hexane fraction, ethyl …
Benign prostate hyperplasia (BPH) merupakan istilah histopatologi yang digunakan untuk menggambarkan pembesaran prostat. Salah satu pengobatan BPH adalah dengan menggunakan terapi obat. Tujuan utama dari terapi obat adalah untuk memperbaiki lower urinary tract symptoms (LUTS). Pengobatan BPH menggunakan satu obat terkadang sulit, oleh karena itu untuk mencapai outcome terapi yang baik dapat men…
Sambiloto leaf extract (Andrographis paniculata) contains secondary metabolites, one of which is flavonoid. Flavonoid have a special compound, quercetin, which has the potential to stimulate probiotic and antibacterial activity. The extract has a bitter taste so that it is formulated in the form of orally dissolving film (ODF) preparation which is expected to cover the bitter taste and provide …
Nyeri merupakan suatu respon sensoris pada tubuh yang menandakan adanya kerusakan jaringan dan menjadi salah satu dari gejala kondisi inflamasi yang terjadi dalam tubuh. Nyeri dan inflamasi dapat ditangani salah satunya menggunakan obat antiinflamasi non steroid (OAINS), tetapi penggunaan OAINS dapat menyebabkan efek samping sehingga dibutuhkan tumbuhan obat dalam terapi nyeri dan inflamasi. Le…
Burn wound are tissue damage caused by contact with heat sources such as fire, hot water, electricity that cause infection, bleeding and affect body systems. The use of chemical synthetic drugs for burns can cause side effects. It is necessary to use natural ingredients that contain anti-inflammatory substances as an alternative in reducing side effects, such as gambir leaves. This study explor…
Melinjo leaves are known to have pharmacological effects as antidiabetics because they contain flavonoid compounds that are able to lower blood glucose levels by reducing glucose and regulating the excretory activity of enzymes seen in carbohydrate metabolism. Bioavailability, effectiveness, and low solubility of extracts in water are major problems in drug formulation. This can be overcome by …
Effective asthma management aims to achieve good asthma control so that patients can live their daily lives optimally and improve their quality of life. This study aims to determine the results of patient demographic data and the relationship between the level of asthma control and the quality of life of adult asthma patients at RSI Siti Khadijah Palembang. This analytic observational study use…