Background: Hyperuricemia is a condition associated with increased systemic inflammatory responses, characterized by elevated levels of tumor necrosis factor alpha (TNF-α) and uric acid. Allopurinol is one of the first-line treatments for hyperuricemia. Cherry leaf (Muntingia calabura L.) is known to contain flavonoids with anti-inflammatory and antihyperuricemic activities. Methods: An in viv…
Alang-alang (Imperata cylindrica (L.) Beauv.) merupakan tumbuhan yang banyak terdapat di Indonesia. Secara kimia alang-alang mengandung manitol, glukosa, sukrosa,malic acid, citric acid, coixol, arundoin, alkali, cylindrin, simiarenol, anemonim, turunan flavonoid, dan damar. Alang-alang memiliki efek antipiretik, diuretik, dan hemostatik. Penelitian ini bertujuan untuk mengetahui efek antipiret…
In 2020–2022, total 787 patients were diagnosed with inguinal hernia at RSUP dr. Mohammad Hoesin Palembang, including lateral inguinal hernia. In various literatures, it is stated that physical workload is the most dominant risk factor among all risk factors for lateral inguinal hernia. This study aims to determine the relationship between physical workload and lateral inguinal hernia. This c…
Hair serum is one of the cosmetic preparations that has a high concentration of active ingredients so that its effectiveness can be felt faster. Tea leaves contain about 42% polyphenolic compounds in the form of catechins that can stimulate cell proliferation in hair dermal papilla cells by suppressing the production of Tumour Necrosis Factor alpha (TNF-alpha) that triggers baldness. This study…
Penelitian ini dilakukan untuk mengetahui aktivitas dari ekstrak daun sungkai (Peronema canescens Jack.) yang memiliki senyawa flavonoid terhadap pertumbuhan dari probiotik Lactobacillus plantarum. Campuran dari ekstrak daun sungkai dan probiotik L. plantarum yang memiliki metabolit sekunder masing-masing diharapkan dapat menghambat bakteri Escherichia coli dengan lebih baik. Uji antibakteri di…
Asam usnat adalah komponen kimia umum yang ditemukan dalam sel lumut dan merupakan komponen kimia dari temuan utama metabolit pada semua spesies Usnea sp. Penggunaan asam usnat sebagai obat masih terbatas karena kelarutannya yang kurang baik dalam air dan termasuk kedalam BCS kelas II. PVP digunakan sebagai pelarut dalam sediaan oral dan sediaan parenteral, dan telah terbukti telah meningkatkan…
Gamal leaves (Gliricidia sepium) contain several secondary metabolites, considered efficacious as hepatoprotector. This study aims to determine the activity of the ethanol extract of Gamal leaves as a hepatoprotector by measuring levels of SGPT, SGOT and ALP and liver histopathology of Wistar male white rats. Mice were divided into six groups: normal group (0.5% Na CMC suspension), positive gro…
One source of antioxidants is phycocyanin from the microalga Spirulina platensis which has pharmacological activity as a natural antioxidant. This study aims to determine the antioxidant activity of phycocyanin from Spirulina platensis microalgae in vitro using the DPPH and FRAP methods. Based on the results of this study, the antioxidant activity of the positive control of vitamin C have IC50 …
Breadfruit leaves (Artocarpus altilis (Park.) Fosberg) are reported to contain flavonoids which have activity as photoprotective agents due to their ability to absorb UV light. This study aims to determine the effect of various extracts on the effect of the anti-erythema activity test of sunscreen gel with HPMC carrier. Sunscreen gels were made with ethyl acetate extract of breadfruit leaves us…
Chitooligosacchride is a complex compound of the glycoprotein group which has a 1,4 glucosamine bond. Chitooligosaccharide as a natural cationic antibacterial agent is widely believed to occur because it interacts and disrupts the structure of the cell wall or cell membrane. This study aims to determine the effect of variations of chitooligosacchride as an anti-acne against Propionibacterium ac…
Asam usnat dapat ditemukan pada lumut, dan terutama melimpah seperti pada genus Alectia, Cladonia, Usnea, Lecanora, Ramalina dan Evernia. Banyak lumut dan ekstrak yang mengandung asam usnat telah digunakan untuk kosmetik dan pengobatan. Asam usnat masih terbilang jarang digunakan dalam pengobatan dikarenakan termasuk dalam BCS kelas II dan tergolong praktis tidak larut dalam air. Pembuatan Oral…
ABSTRACT Drug planning determines the type and amount of drugs aimed at implementing rational drug use and increasing the efficiency of drug use. However, patients often complain about the availability of drugs at the Health Center because of vacancies. This is due to the inaccuracy of drug planning and procurement. This study aimed to analyze drug procurement at the Palembang City Health Cente…
Ischemic stroke is a stroke caused by a blood clot or embolism blocking a cerebral artery. Ischemic stroke occurs in almost 70-85% of cases and is the most common type of stroke. This ischemic stroke disease can be given antiplatelet drug therapy with a mechanism of action in the form of inhibiting platelet aggregation. The use of antiplatelet drugs needs to be investigated to know whether it w…
Clindamycin HCl in conventional topical formulation has a problem in its formulation. It has low bioavalilability, just around 5-8% from total concentration that can be absorbed. In addition, clindamycin HCl also difficult to penetrate into stratum corneum of the skin while Propionibacterium acnes is a bacterium that resides in the sebaceous area of the skin. To overcome this problem, it is nec…
Latar Belakang: Diabetes melitus tipe 2 adalah penyakit kronis yang terjadi ketika pankreas tidak dapat menghasilkan insulin yang cukup atau ketika tubuh tidak bisa lagi menggunakan insulin yang dihasilkan pankreas secara efektif. Indonesia berada di peringkat ketujuh dengan jumlah penderita diabetes melitus terbanyak di dunia yaitu sebanyak 10,7 juta penderita. Keberhasilan terapi untuk pasien…
Background: The essential oil contained in basil leaves can help in the wound healing process. Wound healing process consists of inflammatory, proliferative and remodeling phases. Basil essential oil has been shown to have an anti-inflammatory effect so that it can accelerate the wound healing process. Objective: To determine the effect of basil essential oil extract gel in the number of macrop…
FORMULASI DAN KARAKTERISASI SOLID LIPID NANOPARTICLES ERITROMISIN DENGAN VARIASI JUMLAH ASAM STEARAT SEBAGAI MATRIKS LIPID Gustina Emilia Ningsih 08061281823048 ABSTRAK Eritromisin memiliki kelarutan yang rendah di dalam air yang menyebabkan absorbsi obat lambat dan biovailabilitas rendah didalam tubuh. Salah satu upaya untuk meningkatkan kelarutan eritromisin yaitu dengan diformulasikan menjad…
White tea merupakan olahan tanaman teh (Camellia sinensis L.) yang paling banyak mengandung senyawa polifenol golongan katekin. Katekin mempunyai aktivitas antioksidan yang mampu menghambat reaksi oksidatif pada tubuh. Senyawa katekin bersifat kurang stabil dan mudah rusak sehingga sulit diformulasikan. Pengembangan formulasi ekstrak white tea menjadi bentuk self nano emulsifying (SNE) dilakuka…
Drug solubility is one of important parameter that will affect on drug absorption and drug bioavailability in body. Glibenclamide is belongs to BCS class II which has good permeability in human body but has a low solubility in water. Low solubility of glibenclamide means that only small amount of glibenclamide can be absorbed through the gastrointestinal. One of solutions to increase solubility…
Introduction: Cefixime is used widely and often found inappropriate utilazation. So it needs rasionality of the cefixime utilization in dose, frequency given, length of therapy, route of administration, and interaction with other drugs or other antibiotics. The main objectives of this research is lo know rasionality of the cefixime utilization at Kecamatan Ilir Timur I, Palembang City. Method: …
ABSTRAK Luka terbuka memiliki potensi untuk menjadi infeksi yang kronik bila tidak diobati. Daun Senduduk (Melastoma malabathricum L) mengandung zat flavonoid yang dapat membantu proses penyembuhan luka dengan aktivitas sebagai antiinflamasi, antibakteri, dan antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol daun senduduk terhadap kecepatan penyembuhan luk…
ABSTRAK Luka terbuka dapat berpotensi mengalami infeksi kronik jika tidak diobati. Daun karamunting (Rhodomyrtus tomentosa (Ait) Hassk) mengandung zat utama rhodomyrtone serta flavonoid, tanin, saponin, fenol dan steroid sebagai antibakteri, antiinflamasi dan antioksidan yang dapat membantu proses penyembuhan luka. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol daun…
The ethanol extract of betel leaf has antibacterial activity, namely flavonoids which are unstable to high temperature and intensity, so a polymer-based submicroparticle suspension was made in the form of PLGA and PVA stabilizer. This study aims to determine the effect of variations in the concentration of PVA in the formulation, with flavonoids (quercetin) as the active substance. Preparation …
The lack of stability of betel leaf extract is caused by flavonoid compounds that are easily oxidized by the influence of temperature and high light intensity. Therefore, a suspension based on Chitosan-Alginate polymer was made using the ionic gelation method by reducing the particle size to submicro to increase stability and effectiveness of the active substances in it. This research aims to d…
Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah tanaman tahongai (Kleinhovia hospita L.) yang merupakan famili malvaceae. Ekstrak etil asetat daun tahongai mengandung flavonoid, tanin, saponin dan alkaloid yang diduga memiliki potensi sebagai antidiabetes. Penelitian ini bertujuaan untuk mengetahui potensi ekstrak etil asetat daun tahongai terhadap penurunan ka…
ntioksidan merupakan suatu zat yang mampu menetralisir atau meredam radikal bebas. Tanaman yang berpotensi untuk antioksidan adalah kulit batang cempedak. Pengukuran kadar flavonoid total pada ekstrak kulit batang cempedak menggunakan spektrofotometri Uv-vis didapatkan nilai rata-rata sebesar 0,5417 %. Pengujian aktivitas antioksidan pada penelitian ini dilakukan secara in vivo menggunakan meto…