EVALUASI IN SILICO POTENSI ANTIOKSIDAN SENYAWA AKTIF DALAM EKSTRAK BUAH BIT (…

Stres oksidatif berperan penting dalam patogenesis berbagai penyakit degeneratif melalui pembentukan radikal bebas. Buah bit (Beta vulgaris) diketahui mengandung senyawa bioaktif yang berpotensi sebagai antioksidan alami. Penelitian ini bertujuan untuk mengeksplorasi potensi senyawa aktif dalam ekstrak metanol buah bit sebagai inhibitor enzim pembentuk radikal bebas melalui pendekatan molecular…

FORMULASI KRIM TABIR SURYA EKSTRAK ETANOL DAN FRAKSI DAUN SAMAK (SYZYGIUM URC…

Sun exposure can cause damage to the skin due to ultra violet (UV) radiation. Excessive and prolonged exposure to sunlight can damage the skin layer and can cause negative health effects Additional protection is needed to reduce the transmission of UV rays to the skin and is known as a sunscreen agent. Samak leaf (Syzygium urceolatum (Korth.) Merr. & L.M.Perry) has the potential as a sunscreen …

UJI AKTIVITAS DIURETIK FRAKSI ETIL ASETAT DAUN GAMAL (Gliricidia sepium) TERH…

Hypertension provides a major risk factor for cardiovascular and kidney disease. One of a therapy that used to treat a hypertension is diuretics. Gamal (Gliricidia sepium)contains flavonoid compounds which have diuretic effect. This study aims to determined activity of ethyl acetate fraction of gamal leaves as diuretic by measuring urine volume output and Na⁺, Cl⁻, dan K⁺ ion contents. Th…

UJI AKTIVITAS PENYEMBUHAN LUKA TERBUKA FRAKSI ETIL ASETAT DAUN SINGKONG (Mani…

National injury prevalence tends to increase every year. Wounds must be healed immediately because they are an important role in maintaining homeostasis and have the potential to become chronic infections if not treated. Cassava leaves (Manihot esculenta) contain the main substance rutin or quercetin 3-O-rutinoside (flavonoids) and contain saponins and tannins as anti-inflammatory, antibacteria…

UJI ANTINEFROLITHIASIS FRAKSI ETANOL DAUN KERSEN (Muntingia calabura L.) TERH…

Kidney stone disease (antinefrolithiasis) of calcium stone type is one of the health problems among Indonesian people. The use of diuretic drugs as a treatment for kidney stones can be replaced with natural ingredients to reduce the risk of side effects. Kersen leaves (Muntingia calabura L.) contain a lot of flavanes, flavones, flavanones, flavonols, and chalcones which are included in the flav…

UJI ANTINEFROLITHIASIS FRAKSI ETIL ASETAT DAUN KERSEN (Muntingia calabura L.)…

Kidney stone disease (antinefrolithiasis) of calcium stone type is one of the health problems among Indonesian people. The use of diuretic drugs as a treatment for kidney stones can be replaced with natural ingredients to reduce the risk of side effects. Kersen leaves (Muntingia calabura L.) contain a lot of flavanes, flavones, flavanones, flavonols, and chalcones which are included in the flav…

FORMULASI DAN UJI ANTIOKSIDAN ORALLY DISSOLVING FILM EKSTRAK ETANOL BUNGA KEC…

Kecombrang flower (Etlingera elatior) contains various secondary metabolite compounds, one of which is flavonoids that have antioxidant activity. Orally Dissolving Film (ODF) was formulated to cover the unpleasant taste of kecombrang flowers. Pullulan is used as a polymer due to its ease of solubility in water and has good film-forming properties. This study aims to determine the best formulati…

FORMULASI DAN UJI ANTIOKSIDAN ORALLY DISSOLVING FILM EKSTRAK ETANOL BUNGA KEC…

Kecombrang flower (Etlingera elatior) are plant from the Zingiberaceae family which has potential as an antioxidant. Kecombrang flowers have a distinctive smell and sour taste. The orally dissolving film (ODF) formulation which uses a combination of HPMC polymer and maltodextrin was able to eliminate the unpleasant taste of kecombrang flowers. Orally dissolving film (ODF) preparations was made …

UJI AKTIVITAS ANTIDIABETES FRAKSI ETIL ASETAT KULIT BUAH PISANG KEPOK (MUSA B…

ABSTRAK Kulit pisang kepok, yang mengandung sejumlah senyawa metabolit sekunder seperti flavonoid, telah diketahui memiliki potensi sebagai agen antidiabetes. Penelitian ini bertujuan untuk mengevaluasi seberapa efektif fraksi etil asetat dari kulit pisang kepok dalam menurunkan kadar glukosa darah. Penelitian melibatkan pembagian tikus percobaan ke dalam enam kelompok: kelompok normal (mendapa…

EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID DENGAN METODE ATC/DDD…

Typhoid fever is an acute infectious disease of the small intestine caused by food and drinks contaminated with Salmonella typhi bacteria. The purpose of this study was to determine the profile of antibiotic drug use in typhoid fever patients, to determine the quantitative evaluation and qualitative evaluation of antibiotic use. This study is a descriptive study conducted retrospectively, the d…

ANALISIS HUBUNGAN KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP PASIEN GA…

Hemodialysis is the primary treatment for patients with Chronic Kidney Failure (CKD). CKD Patients experience disruptions in fluid balance, electrolyte levels, acid-base balance, hormone production, and the secretion of toxic metabolic waste. This study aims to analyze the relationship between adherence to medication use and the quality of life of CKD patients with hemodialysis therapy at RSI S…

ANALISIS HUBUNGAN PENGGUNAAN OBAT PENURUN KADAR KOLESTEROL TERHADAP KUALITAS …

Pengobatan yang baik berpengaruh pada tingkat pengetahuan, kepatuhan minum obat penurun kadar kolesterol dan kualitas hidup pasien. Tujuan penelitian ini adalah menganalisis hubungan antara tingkat kepatuhan minum obat dengan kualitas hidup pasien hiperkolesterolemia di Rumah Sakit Islam Siti Khadijah Palembang. Desain penelitian dilakukan secara observasional analitik dengan pendekatan cross-s…

EFEK PREVENTIF FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) SEBAGAI HEP…

Melinjo leaves (Gnetum gnemon L.) is a plan that is often used as a medicinal ingredient because it has a high content of secondary metabolites. Secondary metabolites that are thought to act as hepatoprotectors are flavonoid. This study aims to determine the decrease in SGPT and SGOT levels of various doses, determine ED50 (Effective Dose 50) and determine the effect on the macroscopic and hist…

STANDARISASI DAN UJI TOKSISITAS AKUT EKSTRAK ETANOL RIMPANG TEMU MANGGA (Curc…

Temu mango rhizome (Curcuma amada Roxb.) is one of the plants that has anti-inflammatory and antidiabetic activities. The safety of using temu mango rhizome as a natural medicinal preparation must be supported by scientific research on toxicity testing. This study aims to evaluate the characteristics of acute toxicity of ethanol extract of temu mango rhizome to female Wistar rats using the Acut…

UJI HEPATOPROTEKTOR FRAKSI ETIL ASETAT DAUN MELINJO (Gnetum gnemon L.) DAN GA…

Melinjo leaves (Gnetum gnemon L.) have benefits in the field of traditional medicine. Melinjo leaves (Gnetum gnemon L.) contain secondary metabolite compounds such as flavonoids, saponins, tannins, phenolics, and saponins. This study aims to determine the hepatoprotector activity of ethyl acetate fraction of melinjo leaves (Gnetum gnemon L.) and hepatic histopathological picture of male white r…

STANDARDISASI DAN UJI TOKSISITAS AKUT EKSTRAK ETANOL RIMPANG TEMU IRENG (Curc…

Temu ireng (Curcuma aeruginosa Roxb.) is one of the medicinal plants that has been reported to have antioxidant, antibacterial, anti-inflammatory, and hepatoprotector activities, but this plant has not been widely studied regarding its toxicity. This study conducted an acute toxicity test of ethanol extract of temu ireng rhizome against female Wistar strain rats using the Acute Toxic Class meth…

OPTIMASI DAN KARAKTERISASI DISPERSI PADAT OFLOKSASIN DENGAN VARIASI JUMLAH OF…

Ofloksasin termasuk ke dalam biopharmaceutical classification system (BCS) kelas II dengan kelarutan rendah, yang mengakibatkan bioavailabilitas obat menjadi terbatas. Penelitian ini bertujuan untuk meningkatkan kelarutan ofloksasin dengan memformulasikannya dalam sistem dispersi padat dengan natrium alginat dan kitosan yang digunakan sebagai matriks polimer. Pengembangan formula optimum disper…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN SUNGKAI (PERONEMA CANESCENS JA…

The leaves of Sungkai (Peronema canescens Jack) contain secondary metabolites, flavonoids, which have the potential as antidepressant activity. This study aims to determine the effect of ethanol extract of Sungkai leaves on antidepressant activity and its optimal dose. In this study, six groups were divided: the normal group (NaCMC 0,5% without acute stress induction), the negative group (NaCMC…

UJI AKTIVITAS ANTIOKSIDAN DAUN DAN BUAH TANAMAN BELIMBING WULUH (Averrhoa bli…

Free radicals are unstable molecules that can cause oxidative stress, which contributes to various degenerative diseases such as cancer, diabetes, and cardiovascular disease. Antioxidants play an important role in neutralizing free radicals by donating electrons so as to prevent cell damage. This study aims to determine the antioxidant activity and the correlation between total phenolic and fla…

FORMULASI DAN UJI ANTIBAKTERI LOTION EKSTRAK ETANOL AKAR BAJAKAH KUNING (Cosc…

Plants that have the potential as antibacterials to overcome bacteria that cause body odor (Staphylococcus epidermidis) are ethanol extracts of yellow bajakah roots which contain citral. This study aims to make lotions with various concentrations of ethanol extract of yellow bajakah root (0%, 2%, 4%, and 6%) as antibacterial against Staphylococcus epidermidis. The lotion evaluation test include…

ANALISIS RASIONALITAS TERAPI STROKE ISKEMIK DI RSUD SITI FATIMAH PROVINSI SUM…

Stroke iskemik terjadi akibat penyumbatan arteri serebral yang menghambat aliran darah ke otak, meningkatkan risiko kecacatan dan kematian. Penerapan terapi yang rasional berperan penting dalam efektivitas pengobatan dan pencegahan komplikasi. Penelitian ini bertujuan untuk menganalisis rasionalitas terapi stroke iskemik di RSUD Siti Fatimah Provinsi Sumatera Selatan. Desain penelitian yang dig…

EVALUASI PENGGUNAAN OBAT PADA PASIEN STROKE HEMORAGIK DI RSUD SITI FATIMAH PR…

Hemorrhagic stroke occurs due to bleeding or rupture of blood vessels in the brain that disrupt blood circulation. Hemorrhagic stroke occurs around 10%-20% of all types of stroke with mortality rates reaching 25% to 48%, indicating that hemorrhagic stroke has a high mortality. Rational drug administration in hemorrhagic stroke patients can affect the success of therapy. This study aims to evalu…

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING DALAM MEMPREDIKSI AGEN SKIN WHITEN…

Skin whitening telah menjadi tren global dan banyak digunakan dalam standar kecantikan di berbagai budaya, tetapi produk ini sering menimbulkan efek samping seperti masalah dermatologis dan toksisitas. Upaya dalam mengurangi risiko ini digunakan altenatif bahan alam daun kemang (Mangifera caesia Jack.) yang lebih aman. Senyawa bioaktifnya dapat menghambat aktivitas tirosinase dan mengatur pembe…

NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING EKSTRAK JARAS GAMBIR (UNCARIA GAMB…

Edition

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ISBN/ISSN

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Collation

xxiv, 176 hlm.; ilus.; tab.; 29 cm.

Series Title

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Call Number

T1690782025

STUDI DISPERSI PADAT CEFIXIME DENGAN KOMBINASI KITOSAN DAN VARIASI NATRIUM AL…

Cefixime is a third-generation cephalosporin antibiotic known for its low solubility and permeability. Various technologies have been developed to address this issue, one of which is solid dispersion technology. In this study, chitosan and sodium alginate were used as carrier matrices to produce cefixime solid dispersions. The aim of the study was to evaluate the effect of chitosan and sodium a…

UJI AKTIVITAS NANOEMULSI CITRONELLA OIL DAN CREMOPHOR RH-40 PEMBAWA ASAM USNA…

Usnic acid is a compound with antibacterial, anti-inflammatory properties, and potential in accelerating burn wound healing. Usnic acid has good bioavailability and low solubility in water so it needs to be formulated in a nanoemulsion system with a combination of citronella oil as the oil phase and cremophor RH-40 as a surfactant. This study aims to determine the effect of variations in the co…

UJI AKTIVITAS NANOEMULSI MINYAK CENGKEH DAN CREMOPHOR RH-40 PEMBAWA ASAM USNA…

Lichen is one of the organisms known for its diverse secondary metabolites, one of which is usnic acid. Usnic acid is known to have anti-inflammatory and antibacterial activities to accelerate burn wound healing. This study aims to determine the concentration of clove oil and Cremophor RH-40 from various concentrations to obtain the optimum usnic acid nanoemulsion formula and test its activity …

UJI AKTIVITAS NANOEMULSI MINYAK PEPPERMINT DAN CREMOPHOR RH-40 PEMBAWA ASAM U…

Lichen has a secondary metabolite of usnic acid with antibacterial, antioxidant and anti-inflamatory pharmacological activities, however this compound is classified in Biopharmaceutics Classification System (BCS) class II with low solubility but high permeability so that it becomes an obstacle in topical formulation. This research aims to determine the optimum formula for usnic acid nanoemulsio…

UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL HERBA SIRIH CINA (Peperomia pelluci…

Ethanol extract of Chinese Betel Herb (Peperomia Pellucida (L.) Kunth) is known to contain secondary metabolites, including flavonoid compounds that are thought to have potential antidepressant activity. This study aims to determine the effect of ethanol extract of Chinese betel herb as an antidepressant and determine the best concentration of ethanol extract of Chinese betel herb. Parameters o…

FORMULASI DAN OPTIMASI DISPERSI PADAT OFLOKSASIN DENGAN VARIASI JUMLAH NATRIU…

Ofloxacine is a fluoroquinolone antibiotic that is classified under Biopharmaceutics Classification System (BCS) Class II, characterized by low water solubility and high permeability. This investigation aimed to enhance its solubility by utilizing a combination of sodium alginate and chitosan as carrier polymers in a solid dispersion system. The development of the optimal formulation for ofloxa…