Background: Epilepsy is a chronic condition requiring long-term antiepileptic drug (AED) therapy. Prolonged use of AEDs, particularly first-generation drugs, has been reported to increase the risk of cardiovascular and cerebrovascular events through the process of atherosclerosis. Carotid artery intima-media thickness (IMT) is a sensitive indicator for assessing atherosclerosis. This study aime…
Background: Guillain-Barré Syndrome (GBS) is an acute paralytic polyneuropathy that may progress to respiratory failure and death, with a global prevalence of approximately 1.9 per 100,000 population annually. Two main immunotherapy modalities are recommended as first-line treatments, namely intravenous immunoglobulin (IVIg) and plasmapheresis. Although both therapies have shown comparable eff…
Background: Parkinson's disease is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra. Long-term L-Dopa therapy is associated with the development of motor complications that reduce patients' quality of life. Safinamide is a selective reversible MAO-B inhibitor with an additional mechanism of glutamate release modulation, d…
Background: Diabetes mellitus (DM) is a global health burden with a continuously rising prevalence. Indonesia ranks seventh among countries with the highest number of people living with diabetes, with an estimated 10.7 million patients in 2019. Poor sleep quality is one of the most prevalent comorbidities in patients with DM and has been shown to impair glycemic control. Despite growing evidenc…
Severe acute malnutrition (SAM) remains a global health challenge; Indonesia's wasting rate reached 8.5% in 2023, surpassing the national target of 7%. Children with SAM experience depleted visceral protein stores, including prealbumin, and heightened systemic inflammation reflected by elevated high-sensitivity C-reactive protein (hs-CRP), each condition mutually exacerbating the other. Snakehe…
Severe acute respiratory tract infection (SARI) perpetually constitutes primary causation of hospitalization and mortality within pediatric populations globally, yet data concerning clinical configurations and hospitalization duration determinants in Indonesian pediatric cohorts remain in limitation status. This investigational endeavor harbors objectives to delineate clinical profiles and pati…
Advances in pediatric intensive care have substantially reduced mortality, shifting attention toward long-term morbidity among survivors. Post-intensive care syndrome in children (PICS-p) comprises physical, cognitive, emotional, and social impairments that may persist after discharge. This study aimed to describe PICS-p among pediatric intensive care unit (PICU) survivors. A descriptive observ…
Background: Stroke is a clinical syndrome with an incidence of approximately 12 per 1,000 people in Indonesia, frequently requiring ICU management. Tracheostomy is classified into two types: Percutaneous Dilational Tracheostomy (PDT) and surgical tracheostomy. No specific clinical guidelines exist to determine the optimal tracheostomy technique for stroke patients, highlighting the need for com…
Introduction: Bronchoscopy is a diagnostic and therapeutic procedure that may cause patient discomfort, airway stimulation, and hemodynamic fluctuations. Adequate sedation is therefore required to improve patient tolerance and procedural safety. Dexmedetomidin and midazolam are commonly used sedative agents; however, their comparative effects remain a subject of interest. Methods: This single-b…
Background: Strabismus is a misalignment of the eyes that not only impairs visual function but also affects patients’ psychosocial well-being. Surgical correction of strabismus is expected to improve patients’ quality of life in both functional and psychosocial aspects. Objective: To evaluate the effect of operative intervention on psychosocial and functional quality of life in strabismus p…
Background: Septal deviation is a nasal structural abnormality that requires endoscopic septoplasty to correct respiratory obstruction. This procedure requires proper postoperative management to reduce pain, control bleeding, and minimize complications through trans-septal suturing techniques and nasal packing methods. This study aims to analyze the effectiveness of Polyvinyl Alcohol (PVA) nasa…
Background: The aging process is closely associated with a decline in muscle mass and function as well as a decrease in neurotrophin levels, such as Brain-Derived Neurotrophic Factor (BDNF). Vitamin D deficiency is prevalent among the elderly and is thought to play a role in the pathophysiology of musculoskeletal decline. This study aims to evaluate the effectiveness of Vitamin D supplementatio…
Background: Industrial noise exposure is a major occupational risk factor associated with noise-induced hearing loss (NIHL) and vestibular dysfunction. Continuous exposure to sound levels exceeding 85 dB is known to impair auditory and balance function. This study aimed to examine the correlation between noise intensity and duration of exposure with hearing impairment and balance impairment amo…
Background: Acute Kidney Injury (AKI), the most serious complications in critically ill patients admitted to the Intensive Care Unit (ICU). Under these conditions, the required renal replacement therapy modality that can be performed in the ICU is Continuous Renal Replacement Therapy (CRRT). However, the mortality rate remains high in patient with CRRT. This study aims to analyze the relationsh…
Background: An excessive inflammatory response and dysregulation of the immune system in severe sepsis may progress to septic shock and increase mortality. Vitamin D plays an important role in immune modulation. This study aimed to analyze the association between vitamin D levels and sepsis severity and to determine the cut-off point of vitamin D associated with the risk of septic shock in ICU …
Pendahuluan : Tekanan intraokular (TIO) memainkan peran penting dalam diagnosis dan manajemen beberapa penyakit mata, terutama yang terkait dengan peningkatan tekanan intraokular. Tingginya TIO dan Central Corneal Thickness (CCT) merupakan faktor risiko hilangnya penglihatan. Hingga saat ini Goldmann Applanation Tonometry (GAT) masih menjadi gold standard pengukuran TIO dan telah terdapat beber…
Background: Docetaxel is a chemotherapy drug used to inhibit cell cleavage in nasopharyngeal cancer. Canalicular and ductal stenosis is a common side effect of weekly docetaxel therapy, which often causes epiphora. This study aimed to analyze the correlation between the duration of docetaxel chemotherapy and lacrimal punctum stenosis in patients with nasopharyngeal cancer. Methods: This descrip…
Background: : Centella asiatica has long been used as a wound-healing agent due to its triterpenoid content, which possesses anti-inflammatory, antioxidant, and antifibrotic properties . During the wound healing process, TGF- β regulates re-epithelialization, inflammation, angiogenesis, and granulation tissue formation. Centella asiatica has been shown to decrease TGF-β 1, and contribute to t…
Background: Corneal incisions alter the curvature of the corneal surface, leading to surgically induced astigmatism (SIA). Temporal incisions are generally superior to superior incisions due to improved surgical access and lower SIA values. This study aims to analyze the survival of SIA values resulting from temporal corneal incisions in cataract patients undergoing phacoemulsification. Methods…
Introduction:Breast carcinoma is the most common breast malignancy among women in Indonesia,accounting for 30.8% of female cancer cases in 2020, with high prevalence at Dr. Mohammad Hoesin General Hospital (20.9% in 2019–2020). Serum calcium plays a crucial role in cellular regulation of cancer through homeostasis of PTH, vitamin D, and mechanisms such as PTHrP and local osteolysis, where hyp…
Background The prognosis of advanced-stage lung cancer remains poor despite ongoing therapeutic advances. Systemic inflammation and nutritional status are increasingly recognized as important prognostic determinants. The Advanced Lung Cancer Inflammation Index (ALI) is a prognostic parameter that evaluates the degree of systemic inflammation by combining body mass index (BMI), serum albumin lev…
Latar belakang: Coronary Artery Bypass Graft (CABG) adalah prosedur bedah jantung yang dapat memengaruhi hasil pascaoperasi, termasuk lama perawatan di ICU Kardiovaskular (CV ICU). Durasi CPB dan waktu klem aorta (AoX) yang berkepanjangan diduga berhubungan dengan peningkatan morbiditas serta perpanjangan masa perawatan pascaoperasi. Tujuan: Menentukan hubungan antara lama CPB dan waktu AoX den…
Background Hemorrhagic stroke is a neurological condition with high mortality, particularly in patients requiring mechanical ventilation due to decreased consciousness or respiratory failure. Initial neurological severity, comorbidities, and complications during hospitalization may influence patient outcomes. This study aimed to analyze factors associated with mortality in hemorrhagic stroke pa…
Background: Vascular Cognitive Impairment (VCI) represents a leading cause of post-stroke cognitive impairment in Asia, including Indonesia, with substantial implications for quality of life and economic burden. Current management strategies emphasize early detection through the identification of specific biomarkers as predictive factors. The LDL/ApoB ratio is considered a more accurate surroga…
Background: Stroke is a catastrophic disease with a significant economic burden, particularly for neurointervention procedures such as mechanical thrombectomy and coiling. A disparity exists between standard costs and actual billing charges for these procedures at Dr. Mohammad Hoesin Hospital Palembang. This study aimed to analyze the factors influencing hospitalization costs of stroke patients…
Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed t…
ABSTRACT THE CORRELATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND COGNITIVE FUNCTION IN ELDERLY PATIENTS AT THE GERIATRIC OUTPATIENT CLINIC OF RSMH PALEMBANG Devin Fidela, Yuniza, Nur Riviati, Iche A. Liberty Department of Internal Medicine, Faculty of Medicine, Sriwijaya University Dr. Mohammad Hoesin Hospital Palembang Background: Cognitive impairment represents a major public health c…
Pendahuluan: Proses penuaan menyebabkan penurunan massa otot, kekuatan otot, dan performa fisik (sarkopenia), yang dipengaruhi oleh inflamasi kronik tingkat rendah dengan peningkatan kadar interleukin-6 (IL-6). Extra Virgin Olive Oil (EVOO) mengandung polifenol seperti hydroxytyrosol dan oleuropein yang bersifat antioksidan dan antiinflamasi, berpotensi memperbaiki fungsi otot pada lansia. Tuju…
Latar Belakang: Gangguan tidur pada remaja secara global cukup besar, sekitar 25-30%. Sementara itu gangguan pada proses tidur dapat menimbulkan masalah serius pada kesehatan fisik dan perilaku pada remaja. Tujuan: Mengidentifikasi faktor-faktor yang memengaruhi gangguan tidur pada remaja SMP di Palembang. Metode: Penelitian ini merupakan observasional analitik dengan desain potong lintang pada…
Penelitian ini dilakukan di Sungai Napalan, Desa Umpam, Kecamatan Lengkiti, Kabupaten Ogan Komering Ulu, Sumatera Selatan, yang bertujuan untuk menganalisis karakteristik mikrofosil foraminifera pada batugamping Formasi Baturaja bagian bawah, tengah, dan atas. Metode penelitian meliputi studi pendahuluan, observasi lapangan, analisis laboratorium, serta interpretasi data di studio. Dari 15 loka…