Breadfruit leaves (Artocarpus altilis (Park.) Fosberg) contain flavonoids which have activity and have the potential to act as photoprotective agents because of their ability to absorb UV light. This study aims to determine the effect of variations in the formulation of breadfruit leaf ethyl acetate extract on the effect of activity tests as a sunscreen with Carbomer 940 and Triethanolamine as …
Exposure to direct sunlight for a long time can cause damage to the epidermal tissue of the skin which is a factor in the emergence of erythema and causes skin cancer. Sunscreen is a cosmetic product that functions to protect the skin from exposure to UV rays. Breadfruit leaves (Artocarpus altilis) are reported to contain antioxidant compounds which have the potential to be active ingredients f…
Sambiloto leaves extract (Andrographis paniculata (Burm.f.) Wall. Ex Ness) contains andrographolid and flavonoid main secondary metabolites which have potential as ultraviolet radiation protection and antioxidant activity as photoprotective agents. This research aims to determine the optimization of Tween 80 and Ethanol 96% concentrations to increase their photoprotective and stability. Optimiz…
Daun cempedak (Artocarpus champeden) mengandung metabolit sekunder berupa flavonoid yang memiliki aktivitas antioksidan dan antiinflamasi yang berpotensi dalam memperbaiki fungsi ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etil asetat daun cempedak (EEADC) terhadap volume dan pH urin, kadar kreatinin dan ureum serum, kadar protein urin, klirens kretinin dan gamb…
Catechins compounds in gambier leaves have an antioxidant effect. The purpose of this study is to determine the optimal results of gambir leaf extract and the characteristic of optimal gambier leaf extract. The extraction method used in the study was ultrasoundassisted extraction (UAE). Data analysis was carried out using software design expert 13 with factorial 23. Factors in the extraction pr…
Background: The failure of endodontic treatment is often caused by errors during elimination procedures of Gram-positive bacteria (Enterococcus faecalis) so that it is necessary to use irrigating solutions such as sodium hypochlorite (NaOCl) to eliminate it from the root canal. Prabumulih City’s pineapple leaves (Ananas comosus) are herbal plants that have antibacterial properties due to the …
Daun salam (Syzygium polyanthum [Wight.] Walp.) mempunyai banyak khasiat bagi tubuh, salah satu khasiatnya adalah untuk mengatasi penyakit degeneratif. Telah dilakukan penelitian aktivitas antioksidan dari fraksi etanol daun salam secara in vivo dengan mengukur kadar malondialdehid, aktivitas enzim katalase, makroskopik dan histopatologi hati tikus. Metabolit sekunder yang terdapat di dalam dau…
The main problem in the coffee processing process is the handling of coffee waste. Coffee fruit skin is only used as animal feed. Even though coffee peel extract has potential as an antioxidant because it contains flavonoids, especially catechins. Coffee pod extract has low solubility and bioavailability, so it is formulated in a self-nanoemulsifying (SNE) form. SNE) is able to increase solubil…
Oxidative stress can cause degenerative diseases such as cancer, diabetes, heart disease and stroke, antioxidants are needed to overcome this. One of the Indonesian plants that has the potential as an antioxidant is cardia (Bellucia pentamera Naudin). Based on the results of the phytochemical screening, kardia leaves contain secondary metabolites which have pharmacological activity as antioxida…
Daun melinjo memiliki aktivitas farmakologis sebagai antidiare, antihiperlipidemia, antidiabetes, antioksidan, dan diuretik. Tujuan penelitian ini untuk mengetahui toksisitas subkronis fraksi etil asetat daun melinjo terhadap tikus putih jantan galur Wistar. Pada penelitian ini dibagi menjadi 5 kelompok yaitu kelompok kontrol (Na-CMC 0,5%) dan 4 kelompok perlakuan yang terdiri dari dosis 40 mg/…
Inflamasi dapat menyebabkan rasa kurang nyaman pada penderita akibat edema yang ditimbulkan, sehingga diperlukan obat antiinflamasi. Daun cempedak mengandung flavonoid yang berpotensi sebagai antiinflamasi dengan kemampuannya menghambat pembentukan prostaglandin. Proses penghantaran zat aktif akan lebih efektif apabila dilakukan dalam bentuk suatu sediaan seperti sediaan transdermal patch. Komp…
Fraksi etil asetat daun melinjo memiliki efek terapi sebagai antihiperlipidemia dan antidiare. Skrining fitokimia fraksi etil asetat daun melinjo mengandung senyawa tanin, fenolik, dan flavonoid. Senyawa yang terkandung pada fraksi etil asetat daun melinjo belum tentu aman, sehingga perlu diuji keamanannya dengan pengujian toksisitas. Penelitian ini telah dilakukan uji toksisitas akut fraksi et…
Purple sweet potato leaves (Ipomoea batatas L.) is a traditional medicine so it is necessary to carry out safety tests, one of which is the subchronic toxicity test. This study aims to determine the effect subchronic toxicity of the ethyl acetate fraction of purple sweet potato leaves on male white rats of the Wistar strain. In this study, they were divided into 4 groups including the control g…
Daun jengkol (Archidendron jiringa) merupakan salah satu tanaman yang memiliki aktivitas antiinflamasi dan antihiperurisemia. Hasil skrining fitokimia menunjukkan ekstrak etanol daun jengkol mengandung senyawa saponin, tanin, flavonoid, dan steroid. Keamanan penggunaan daun jengkol sebagai bahan sediaan obat alami harus didukung oleh penelitian ilmiah mengenai pengujian toksisitas. Pada penelit…
Purple sweet potato leaves has activities as a medicine for boils, antipyretic, burns, hepatoprotectors, antioxidants and it is known that the ethyl acetate fraction of purple sweet potato leaves has antihyperlipidemic activity. The use of purple sweet potato leaves as a natural medicine must be supported by toxicity studies to ensure the safety of its use. The purpose of this study was to dete…
Jicama flour (Pachyrhizus erosus) contains an oligosaccharide compound in the form of inulin which acts as a natural prebiotic with low levels, so it needs to be modified to improve its prebiotic properties. This study aims to modify yam flour into resistant starch (RS3). Analysis was carried out on jicama flour without modification and modification by fermentation and autoclaving-cooling 3 cyc…
Sumatran elephants is one of large mammal distributed along the island of Sumatra. The population of Sumatran elephants (Elephas maximus sumatranus) may decline if there are no activities that refer to conservation, especially in wild populations. The main problem of elephant conservation is interaction with humans which causes habitat loss and degradation that affects elephant feeding activiti…
Purple sweet potato leaves (Ipomoea batatas L.) have been tested for acute toxicity at a dose of >2000 mg/KgBB which is classified as practically non-toxic, so further testing is required for teratogenic tests. The purpose of this study was to determine the level of safety of purple sweet potato leaves for the fetus when consumed by pregnant women. In this study, 4 treatment groups were used, n…
Butterfly pea flowers (Clitoria ternatea L.) contains secondary metabolites of anthocyanins and flavonoids which have antidiabetic activity. The purpose of this study was to determine the effectiveness of lowering blood glucose levels of the ethanol fraction of butterfly pea flowers. The experimental divided into 6 groups namely normal and negative control groups with 0.5% NaCMC, positive contr…
Kencana Ungu (Ruellia tuberosa L.) leaves are known to contain secondary metabolites of flavonoids which have antidiabetic activity. The purpose of this research was to determine the effectiveness of reducing blood glucose levels of the ethyl acetate fraction of kencana ungu leaves. This study was divided into 6 groups, namely the normal group (0.5% Na-CMC suspension), positive control (1 IU/kg…
Kersen (Mutingia calabura L.) leaves have pharmacological effect as antioxidant, antibacterial, anti-inflammatory, antihyperuricemia, antiobesity, antidiarhheal, antihyperlipidemic, analgesic, anthelmintic. Kersen leaves contain secondary metabolites, alkaloid, flavonoid, tannin, saponin, steroids. High flavonoid compounds require toxicity testing. This study aimed to determine the acute toxici…
Spirulina platensis contains flavonoids and carotenoids which have pharmacological activity as antioxidants. This study aims to determine the content of phenolic and carotenoid compounds and antioxidant activity contained in Spirulina platensis microalgae using the DPPH (1,1-diphenyl-2-pikrihidrazyl) and FRAP (Ferric-Reducing Antioxidant Power) methods. The content of phenolic compounds obtaine…
Daun ketepeng cina diketahui memiliki efek farmakologi sebagai antidiabetes alami dikarenakan mengandung senyawa flavonoid berupa kuarsetin yang mampu menghambat enzim α-glukosidase untuk menurunkan kadar glukosa dalam darah. Efektivitas dan bioavailibilitas ekstrak yang cenderung rendah sehingga dibuat sediaan dengan sistem penghantaran nanopartikel. Penelitian ini bertujuan untuk memformulas…
Ethanol extract of temu ireng rhizome (Curcuma aeruginosa Roxb.) contains many efficacious secondary metabolites, one of which is flavonoid, phenolic, and curcuminoid. The compound is thought to have the potential to be gastroprotective. This research aimed to determine the effect of differences in the dose of ethanol extract of temu ireng rhizome as gastroprotective on the evaluation parameter…
Kepok banana (Musa paradisiaca formatypica) contains inulin and fructooligosaccharide (FOS) which act as natural prebiotics. This research was conducted to analyze the effect of kepok banana flour before and after modification with high pressure heating on the growth of L. plantarum using Design Expert 12®. Test standardization of the quality of banana flour kepok based on SNI 01-3751-2009. Mo…
Research has been carried out on the anti-oxidant potence of kecombrang (Etlingera elatior), which includes the determination of total phenolic content and antioxidant activity of the extract, and the fractions of the kecombrang (E.elatior) plant. Determination of total phenolic content with gallic acid standard using Follin Ciocalteu reagent. The principle of this test is the formation of a bl…
Daun pucuk idat mengandung metabolit sekunder yaitu flavonoid, saponin, tanin, triterpenoid, steroid, dan fenolik yang memiliki aktivitas farmakologi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui karakteristik ekstrak etanol, pengaruh pemberian ekstrak etanol dan fraksi daun pucuk idat terhadap aktivitas antioksidan dengan mengukur kadar MDA, penentuan aktivitas enzim katalase,…