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PROFIL STRES OKSIDATIF DAN MIKROANATOMI OTAK PEMBERIAN SELF-NANOEMULSIFYING D…
Stres oksidatif dapat menimbulkan kerusakan DNA sehingga dapat menurunkan fungsi kognitif. Katekin pada teh putih memiliki efek farmakologis sebagai antioksidan dapat dijadikan terapi peningkatan fungsi kognitif. Penelitian bertujuan untuk mengetahui nilai profil stres SOD, CAT, dan MDA serta mengetahui gambaran histopatologi hippokampus dan sel neuron. Penelitian menggunakan rancangan post tes…
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- xv, 93 hlm.; ilus.; 29
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- T890102023
PENGARUH PEMBERIAN FRAKSI N-HEKSAN DAUN UBI JALAR UNGU TERHADAP ALIRAN DAN PA…
Daun ubi jalar ungu (Ipomoea Batatas (L.) Lam.) mengandung senyawa beta-karoten yang memiliki efek farmakologis sebagai antiaterosklerosis. Penelitian ini bertujuan untuk melihat aktivitas fraksi n-heksan daun ubi jalar ungu dalam mengembalikan aliran dan faktor koagulasi darah tikus serta pengaruhnya terhadap gambaran histopatologi aorta tikus yang diinduksi suplemen tinggi lemak. Pada penelit…
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- ix, 95 hlm.; ilus.; 29 cm
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- T890962023
UJI AKTIVITAS ANTIOKSIDAN SEDIAAN NANOEMULSI MINYAK BIJI RAMI (Linum usitatis…
Flaxseed oil (Linum usitatissimum) has been shown to enhance the function of the antioxidant system due to its antioxidant compounds such as phenols and vitamin E. The development of flaxseed oil into stable dosage forms such as nanoemulsions is very potential from the point of view of the efficacies contained. This research was conducted to determine the concentration of flaxseed oil in nanoem…
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- xviii, 94 hlm.; ilus.; 29 cm
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- T893412023
UJI AKTIVITAS ANTIOKSIDAN SEDIAAN NANOEMULSI MINYAK SACHA INCHI (Plukenetia v…
Minyak Sacha Inchi (Plukenetia Volubilis L.) mengandung senyawa bioaktif yang bersifat antioksidan diantaranya yaitu flavonoid dan beberapa asam lemak tinggi yakni asam palmitat, asam stearat, asam oleat, asam linoleat, dan asam linolenat. Penelitian ini bertujuan untuk menentukan konsentrasi minyak sacha inchi dalam sediaan nanoemulsi yang memiliki aktivitas antioksidan terbaik kemudian dianal…
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- xvii, 84 hlm.; ilus.; 29 cm
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- T893252023
PENGARUH PEMBERIAN FRAKSI ETIL ASETAT DAUN UBI JALAR UNGU TERHADAP ALIRAN DAN…
Purple sweet potato leaves are plants that contain secondary metabolites of flavonoids, tannins and phenolics which are proven to have activity as a vasodilator and are able to increase the formation of Nitric Oxide (NO) as so as reducing atherosclerosis. The purpose of this study was to determine the effect of giving the ethyl acetate fraction of purple sweet potato leaves on blood flow and bl…
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- iv, 60 hlm.; ilus.; 29 cm
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- T890662023
PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK BUAH MENGKUDU (Morinda citr…
Noni fruit (Morinda citrifolia L.) contains flavonoids that have immunomodulatory activity. Orally Dissolving Film (ODF) formulation removes the bitter taste and low bioavailability of extract. This study aims to determine the characteristics of ODF noni fruit extract and the immunomodulatory effects of ODF noni fruit extract in Wistar male rats induced by E. coli on the number of leukocytes, l…
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- xviii, 135 hlm.; ilus.; 29 cm
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- T1141362023
FORMULASI EKSTRAK DAUN GAMBIR (UNCARIA GAMBIR ROXB.) SEBAGAI KOSMETIK PEMBERS…
Catechins are flavonoid compounds that contain antioxidants that can prevent cell damage from free radicals and reduce excess melanin production by inhibiting the tyrosinase enzyme. Delivery of active substances is more effective when done in dosage forms, so gambir extract is formulated into facial cleansers that can deliver active substances properly. This study aims to obtain an optimum form…
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- xix, 101 hlm.; ilus.; 29 cm
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- T1050322023
PENGARUH PEMBERIAN ORALLY DISSOLVING FILM EKSTRAK DAUN KENIKIR (Cosmos caudat…
Kenikir leaves (Cosmos caudatus. Kunth) contain various secondary metabolic compounds, quercetin which has the potential as an immunomodulator. This study aims to determine number of leukocytes, lymphocytes, neutrophils, monocytes, CD4 T cells, ODF ethanol extract film of kenikir leaves in Wistar rat strain and macroscopic and histopathalogic images of spleen organs. The research used Spektrofo…
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- xviii, 146 hlm.; ilus.; 29 cm
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- T1140462023
OPTIMASI KONSENTRASI TWEEN 80 DAN PEG-400 DALAM SEDIAAN NANOEMULSI DAUN SAMBI…
Sambiloto leaves (Andrographis paniculata (Burm. f.) Wall. Ex Ness) has the potential as a photoprotective agent with a high content of quercetin and andrographolide. The preparation of Sambiloto leaves nanoemulsion was carried out to increase its photoprotective activity and stability. This study aims to determine the optimum concentration of Tween 80 and PEG-400 in the Sambiloto leaves nanoem…
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- xviii, 82 hlm.; ilus.; 29 cm
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- T944682023
EFEK PEMBERIAN SNACK BAR EKSTRAK DAUN PEGAGAN (Centella asiatica L.) KOMBINAS…
Cognitive function improvement is an ability to organize information for the better. One of the methods to improve it is functional food. Gotu kola leaves (Centella asiatica L.) and purple sweet potato (Ipomoea batatas L.) have high antioxidant contents of flavanoid, asiaticoside, triterpenoid, and anthocyanin compounds which are able to counteract free radicals. This research aims at determini…
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- xx, 91 hlm.; ilus.; 29 cm
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- T888232023
AKTIVITAS ANTIINFLAMASI TRANSDERMAL PATCH EKSTRAK DAUN MELINJO (Gnetum gnemon…
Inflammation can cause an uncomfortable response due to pain. Plants that can be used as anti-inflammatory come from melinjo leaf at dose of 563 mg/kg BB. Delivering the active substance is carried out as a transdermal patch. The use of plasticizers can improve the mechanical properties of patch preparations. This study aims to obtain the best formula for transdermal patch preparations for anti…
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- xvii, 102 hlm.; ilus.; 29 cm
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- T949402023
EFEK PEMBERIAN SELF-NANO EMULSION EKSTRAK WHITE TEA TERHADAP PROFIL INSULIN, …
White tea contains catechins which have pharmacological effects as antioxidants. This study used test animals in the form of male Wistar rats which were divided into seven groups: normal group, negative control (STZ-NA induced), positive control (STZ-NA and Glibenclamide induced), group 1 (STZ-NA induced and SNE base). , Group 2 (induced STZ-NA and SNE-white tea extract), group 3 (induced STZ-N…
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- xvii, 125 hlm.; ilus.; 29 cm
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- T889302023
UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN SUNGKAI (Peronema canescens Jack) PADA…
Pain is a sign that something wrong in the body system such as tissue problem, also it is one of the most complaints when patient sees doctor. Pain can be treated with analgesic drug. One of plant which is widely used as an herbal medicine is Peronema canescens. The leaves of P. canescens has been reported contained betulinic acid, glycoside, β-sitosterol, stigmaterol and phytol. The aims of t…
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- x, 128 hlm.; ilus.; 29 cm
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- T892992023
APLIKASI FULL FACTORIAL DESIGN 2^3 PADA OPTIMASI PROSES EKSTRAKSI KULIT BUAH …
Senyawa flavonoid antosianin pada kulit buah kopi robusta mempunyai aktivitas antioksidan yang tinggi. Penelitian ini bertujuan untuk mengetahui hasil proses optimasi ekstrak kulit buah kopi robusta menggunakan full factorial design serta karakteristik ekstrak optimal. Metode ekstraksi yang digunakan berupa ultrasound-Assisted Extraction (UAE) dan dianalisis dengan full factorial design 23 (FFD…
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- xvii, 120 hlm.; ilus.; 29 cm
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- T890182023
EFEK PEMBERIAN SNACK BAR EKSTRAK DAUN PEGAGAN (Centella asiatica L.) KOMBINAS…
Gotu Kola ( Centella asiatica ) and cocoa ( Theobroma cacao L. ) one of the plants believed to have many benefits. The High antioxidant content, especially flavonoids, triterpenoids, polyphenols, saponins from gotu kola and cocoa beans are believed to increase memory or improve memory. This study aims to determine levels of flavonoids, levels of proximate characteristics of Snack bars , and to …
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- xviii, 95 hlm.; ilus.; 29 cm
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- T888482023
OPTIMASI DAN KARAKTERISASI PATCH TRANSDERMAL EKSTRAK ETIL ASETAT DAUN GAMBIR …
Ekstrak daun gambir mengandung berbagai senyawa metabolit sekunder salah satunya flavonoid. Flavonoid sendiri memiliki berpotensi sebaagai analgetik dan antiinflasmasi. Proses penghantaran zat aktif ini akan lebih efektif apabila dilakukan dalam bentuk suatu sediaan. Salah satu bentuk sediaan tersebut adalah patch transdermal. Komponen penting pada sediaan patch adalah polimer sehingga pada pen…
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- xix, 139n hlm.; ilus.; 29 cm
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- T889702023
UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL DAUN SEMPRAWANG (Dillenia ochreata) PA…
The ethanol extract of Dillenia ochreata leaves contains secondary metabolites such as triterpenoids, steroids, phenolics and flavonoids which have potential as analgesics with the ability to inhibit prostaglandins as the main mediators of pain. The aims of this study to determine the best dose of the ethanol extract from D. ochreata leaves through the hot plate test, to determine the location …
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- xvii, 107 hlm.; ilus.; 29 cm
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- T892922023
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAN FRAKSI DAUN BALIK ANGIN (MALLOTU…
One of the plants that has the potential as a natural antioxidant is balik angin plant (Mallotus paniculatus (Lam.) Mull. Arg.). Based on the results of the phytochemical screening, the leaves of balik angin contain flavonoids, steroids, triterpenoids, saponins, tannins and phenolics. This study was aimed to determine the characteristics of the extract and the antioxidant activity of the ethano…
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- xix, 118 hlm.; ilus.; 29 cm
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- T911652023
EFEK INHIBISI ENZIM XANTIN OKSIDASE EKSTRAK DAN FRAKSI POLAR ETIL ASETAT DAUN…
Introduction: Hyperuricemia is a condition where uric acid levels are above normal levels (> 7 mg/dL in women and > 6 mg/dL in men) and can cause negative impact on a person's body if left untreated. Long term hyperuricemia will lead to gout arthritis, kidney stones and increase risk factor of hyperlipidemia, diabetes, hypertension and other cardiovascular diseases. So far, allopurinol is the f…
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- xix, 109 hlm.; ilus.; 29 cm
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- T845612023
UJI DAYA ANTIBAKTERI EKSTRAK ETANOL RAMBUT JAGUNG (ZEA MAYS SACCHARATA STURT)…
Background: Periodontal disease is the second most frequent dental and oral health problem In Indonesia. Porphyromonas gingivalis, prevalent in subgingival plaques, is the primary bacteria that cause periodontal disease. Periodontal disease can be prevented mechanically, chemically, or spontaneously by inhibiting plaque growth. Natural ingredients such as corn hair, which include antibacterial …
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- xiv, 39 hlm.; ilus.; 29 cm
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- T711562022
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL MAHKOTA DAUN NANAS (Ananas comosus) …
Background: Staphylococcus aureus is a pathogen that caused some oral infections. The use of antibacterial agents such as Chlorhexidine can eliminate Staphylococcus aureus, but may exhibit side effects, such as oral mucosa irritation, taste perception alteration, burning sensation, and tooth staining. Therefore, Ananas comosus crown leaf is used as an alternative therapy because it has antibact…
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- xiv, 49 hlm.; ilus.; 29 cm
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- T741242022
UJI INHIBISI FRAKSI ETIL ASETAT BATANG KAYU KUNING (ARCANGELISIA FLAVA) TERHA…
Latar belakang: Kayu kuning memiliki kandungan metabolit sekunder berupa flavonoid yang diteliti dapat menghambat enzim xantin oksidase yaitu enzim yang mengkatalisis pembentukan asam urat sehingga berpotensi sebagai pengobatan alternatif hiperurisemia. Tujuan: Untuk mengetahui efek inhibisi fraksi etil asetat dari ekstrak etanol 96% batang kayu kuning terhadap enzim xantin oksidase Metode: Sim…
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- xvii, 78 hlm.; ilus.; 29 cm
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- T835082022
EFEKTIVITAS FRAKSI POLAR EKSTRAK ETIL ASETAT DAUN KERSEN (Muntingia calabura …
Background: Xanthine oxidase is an enzyme that catalyzes the formation of uric acid. It is known that kersen leaves contains secondary metabolites such as flavonoids, which have antihyperuricemia potential. This study aims to determine the efficacy of the polar fraction of ethyl acetate extract of kersen leaves (Muntingia calabura Linn) as an antihyperuricemia tested in vitro. Methods: Experime…
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- xviii, 95 hlm.; ilus.; 29 cm
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- T841362022
EFEK INHIBISI EKSTRAK DAN FRAKSI NONPOLAR ETIL ASETAT DAUN BENALU KERSEN TERH…
Introduction: Kersen plant (Muntingia calabura L.) is known to contains flavonoids, triterpenoids, tannin and alkaloids which have ability to inhibit xanthine oxidase enzyme in vivo and in vitro. These metabolite compounds is worked by binding to the active site of xanthine oxidase enzyme thereby preventing substrate to binding with xanthine oxidase enzyme. Benalu kersen leaves (Dendrophthoe pe…
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- xviii, 159 hlm.; ilus.; 29 cm
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- T841282022
UJI INHIBISI FRAKSI ETANOL BATANG KAYU KUNING (ARCANGELISIA FLAVA MERR) TER…
Background: Xanthine oxidase is an enzyme that catalyzes the formation of uric acid. Secondary metabolites that have a potential as xanthine oxidase inhibitor or antihyperuricemia are flavonoids, alkaloids, terpenoids, saponins, and tannins. From the latest research, ethanol extract of the stem of kayu kuning contains secondary metabolites such as flavonoids, alkaloids, terpenoids, saponins, an…
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- xv, 59 hlm.; ilus.; 29 cm
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- T835382022
UJI POTENSI ANTIBAKTERI EKSTRAK DAUN KIRINYUH (Chromolaena odorata) DENGAN VA…
Kirinyuh plant (Chromolaena odorata (L.) RM King & H. Rob.) is one of the plants used as traditional medicine that has antibacterial potential. This research aims todetermine the antibacterial potential of kirinyuh leaf extract (Chromolaena odorata) and determine the values of Minimum Inhibitory Concentration (MIC) and Minimum Killing Concentration (KBM) against Streptococcus viridans bacteria.…
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- xvi, 53 hlm.; ilus.; 29 cm
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- T772362022
OPTIMASI FORMULA MASKER PEEL OFF EKSTRAK ETANOL 70% BUNGA TELANG (Clitoria te…
Butterfly pea flower (Clitoria ternatea) contains phenolic compounds which are efficacious as antioxidants that can overcome various skin damage. Peel off masks are popular topical formulation because they are unique and practical. One of the important components of peel off masks is the gelling agent PVA as a film-forming agent. However, PVA at the wrong concentration can result in poor mask p…
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- xvi, 86 hlm.; ilus.; 29 cm
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- T771692022
OPTIMASI DAN KARAKTERISASI TRANSETOSOM FRAKSI ETIL ASETAT EKSTRAK KULIT BUAH …
The mangosteen rind (Garcinia mangostana L.) are proven contains a xanthone-derived bioactive compound in the form of α-mangostin which has ability as an anti-tyrosinase. The ability of transethosomes to penetrate through the stratum corneum can increase the pharmacokinetic value and pharmacological effects of the fractions used. This study aims to determine the optimum formula of varying conc…
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- xviii, 102 hlm.; ilus.; 29 cm
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- T772202022
OPTIMASI FORMULA GRANUL EKSTRAK ETANOL BUAH KURMA AJWA (Phoenix dactylifera L…
Ajwa dates contain flavonoid compounds that have antioxidant activity that can inhibit and bind reactions from free radicals. The purpose of this study was to determine optimization of formula granule of ethanol extract ajwa dates that are practical, consumable and have antioxidant activity. The granule dosage form was chosen because this dosage form is more stable if stored for a long time, ha…
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- xvii, 134 hlm.; ilus.; 29 cm
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- T803582022
FORMULASI SEDIAAN TABLET FRAKSI ETIL ASETAT DAUN KELOR (Moringa oleifera L.) …
Pemanfaatan antioksidan pada daun kelor diformulasikan dalam bentuk sediaan tablet dengan tujuan kepraktisan dan stabilitas zat aktif. Tujuan penelitian ini untuk mengetahui variasi PVP dan amprotab sebagai pengikat dan penghancur guna menentukan karakteristik formula terbaik tablet yang akan dianalisis dengan program SPSS®16 One Way ANOVA. Penelitian ini menggunakan fraksi etil asetat daun ke…
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- xviii, 95 hlm.; ilus.; 29 cm
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- T803262022
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